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Review

Infertility: A practical framework

Rebecca Flyckt, MD and Tommaso Falcone, MD, FRCSC, FACOG
Cleveland Clinic Journal of Medicine July 2019, 86 (7) 473-482; DOI: https://doi.org/10.3949/ccjm.86a.18068
Rebecca Flyckt
Director, Fertility Preservation Program, Obstetrics, Gynecology and Women’s Health Institute, Cleveland Clinic
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  • For correspondence: [email protected]
Tommaso Falcone
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Tables

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    TABLE 1

    Common causes of infertility

    Pelvic disease (tubal disease, fibroids, endometriosis)
    Male factor
    Disorders of ovulation
    Female reproductive aging
    Idiopathic
    • View popup
    TABLE 2

    Fertility tests that are no longer used in clinical practice

    Postcoital testing
    Routine laparoscopy or hysteroscopy for unexplained infertility
    Endometrial biopsy for endometrial dating
    Prolactin, unless in cases of anovulation or oligo-ovulation
    Advanced sperm function testing
    Thrombophilia or immunologic testing
    Parental karyotyping
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    TABLE 3

    World Health Organization reference values for semen analysis, 2010

    ParameterLower reference value
    Ejaculate volume1.5 mL
    pH7.2
    Sperm concentration15 million/mL
    Total sperm number39 million sperm per ejaculate
    Percent motility40%
    Forward progression32%
    Sperm morphology (% normal forms by Kruger strict criteria)4%
    • Information from reference 33.

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    TABLE 4

    Common causes of anovulation

    Polycystic ovary syndrome
    Hypothalamic amenorrhea due to extreme nutritional, emotional, or physical stressors
    Menopause
    Hyperprolactinemia
    Thyroid disease (hyperthyroidism, hypothyroidism)
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Cleveland Clinic Journal of Medicine: 86 (7)
Cleveland Clinic Journal of Medicine
Vol. 86, Issue 7
1 Jul 2019
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Infertility: A practical framework
Rebecca Flyckt, Tommaso Falcone
Cleveland Clinic Journal of Medicine Jul 2019, 86 (7) 473-482; DOI: 10.3949/ccjm.86a.18068

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Infertility: A practical framework
Rebecca Flyckt, Tommaso Falcone
Cleveland Clinic Journal of Medicine Jul 2019, 86 (7) 473-482; DOI: 10.3949/ccjm.86a.18068
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  • Article
    • ABSTRACT
    • MANY PATIENTS SEEK INFORMATION
    • FAILURE TO CONCEIVE AFTER 1 YEAR
    • AN EMOTIONAL ISSUE
    • LOOK FOR CLUES
    • QUESTIONS OFTEN ASKED BY COUPLES TRYING TO CONCEIVE
    • A PRACTICAL FRAMEWORK FOR EVALUATING THE INFERTILE COUPLE
    • OVARIAN RESERVE TESTING AND FEMALE REPRODUCTIVE AGING
    • FEMALE PERITONEAL AND STRUCTURAL CAUSES
    • MALE FACTOR INFERTILITY
    • ANOVULATION
    • REFERENCES
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  • Info & Metrics
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