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- Figure 1
A large granular lymphocyte.
- Figure 2
The patient’s clinical course: factor VIII inhibitor response to treatment.
Tables
Test Valuea Reference range White blood cell count 8.91 × 109/L 3.70–11.00 Red blood cell count 5.16 × 1012/L 3.90–5.20 Hemoglobin 14.6 g/dL 11.5–15.5 Hematocrit 44.5% 36.0%–46.0% Platelet count 251 × 109/L 150–400 Neutrophils 60.6% 40%–60% Lymphocytes 34.1% 20%–40% Monocytes 4.7% 2%–8% Eosinophils 0.4% 1%–4% Basophils 0.2% 0.5%–1% ↵a Abnormal results are shown in bold.
Prolonged prothrombin time (PT), normal activated partial thromboplastin time (aPTT) Factor VII deficiency or factor VII inhibitor Liver disease Vitamin K deficiency Warfarin use Disseminated intravascular coagulation Normal PT, prolonged aPTT Deficiency of intrinsic pathway factors (VIII, IX, XI, XII) or inhibitors of these clotting factors von Willebrand disease (if factor VIII is very low) Heparin use Lupus anticoagulant (usually associated with thrombosis instead of bleeding) Prolonged PT and aPTT Deficiency of common pathway factors (II, V, X, or fibrinogen) Severe liver disease Vitamin K deficiency Warfarin use Disseminated intravascular coagulation Heparin overdose Normal PT and aPTT with bleeding Platelet dysfunction (acquired or congenital) von Willebrand disease (if factor VIII is mildly decreased) Scurvy Ehlers-Danlos syndrome Hereditary hemorrhagic telangiectasia Factor XIII deficiency Hyperfibrinolysis
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- Article
- EVALUATION FOR AN ISOLATED PROLONGED aPTT
- FACTOR VIII INHIBITOR EVALUATION
- TREATMENT OF ACQUIRED HEMOPHILIA A
- CASE CONTINUED: TREATMENT, LYMPHOCYTOSIS
- EVALUATING LYMPHOCYTOSIS
- CASE CONTINUED: LARGE GRANULAR LYMPHOCYTES
- LGL LEUKEMIA: CLASSIFICATION AND MANAGEMENT
- LGL LEUKEMIA AND AUTOIMMUNE DISEASE
- ACQUIRED HEMOPHILIA A AND HEMATOLOGIC MALIGNANCY
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