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Review

Community-acquired pneumonia: Strategies for triage and treatment

Anita R. Modi, MD and Christopher S. Kovacs, MD
Cleveland Clinic Journal of Medicine March 2020, 87 (3) 145-151; DOI: https://doi.org/10.3949/ccjm.87a.19067
Anita R. Modi
Department of Infectious Disease, Cleveland Clinic
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  • For correspondence: [email protected]
Christopher S. Kovacs
Department of Infectious Disease, Cleveland Clinic; Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
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  • Article
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Article Figures & Data

Figures

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  • Figure 1
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    Figure 1

    Focal lobar pneumonia.

  • Figure 2
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    Figure 2

    Diffuse interstitial pneumonia.

Tables

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    TABLE 1

    The CURB-65 calculator

    CriteriaPoints
    CConfusion1
    UUrea > 7 mmol/L1
    RRespiratory rate > 30 breaths per minute1
    BSystolic blood pressure < 90 mm Hg1
    or diastolic blood pressure < 60 mm Hg
    65Age ≥ 651
    Level of care requiredTotal score
    Outpatient0–1
    Inpatient2
    Intensive care3–5
    • Based on information in reference 1.

    • View popup
    TABLE 2

    Pneumonia Severity Index calculator and associated risk classes

    Risk factorPoints
    Demographics
    MenAge (years)
    WomenAge (years) – 10
    Nursing home resident+10
    Comorbidities
    Neoplasm+30
    Liver disease+20
    Heart failure+10
    Stroke+10
    Renal failure+10
    Physical examination findings
    Altered mental status+20
    Respiratory rate > 30 breaths per minute+20
    Systolic blood pressure < 90 mm Hg+20
    Temperature < 95°F or > 104°F+15
    Heart rate > 125 beats per minute+10
    Laboratory and radiographic findings
    Arterial pH < 7.35+30
    Blood urea nitrogen > 30 mg/dL+20
    Sodium < 130 mmol/L+20
    Glucose > 250 mg/dL+10
    Hematocrit < 30%+10
    Partial pressure of arterial oxygen < 60 mm Hg+10
    Pleural effusion+10
     Risk classTotal points
     I< 51
     II51–70
     III71–90
     IV91–130
     V> 130
    • From Fine MJ, Auble TE, Yealy DM, et al. A prediction rule to identify low-risk patients with community-acquired pneumonia. N Engl J Med 1997; 336(4):243–250. Copyright 1997, Massachusetts Medical Society. Reprinted with permission from the Massachusetts Medical Society..

    • View popup
    TABLE 3

    Severe pneumonia: Infectious Diseases Society of America and American Thoracic Society criteria

    Major criteria
    Respiratory distress requiring mechanical ventilation
    Septic shock
    Minor criteria
    Confusion
    Respiratory rate > 30 breaths per minute
    Blood urea nitrogen > 7 mmol/L
    Leukopenia resulting from infection
    Thrombocytopenia
    Hypothermia
    Hypotension requiring aggressive fluids
    PaO2 / FiO2 < 250
    Multilobar infiltrates
    Having at least 1 major criterion or at least 3 minor criteria suggests the need for intensive care.
    • From Mandell LA, Wunderink RG, Anzueto A, et al; Infectious Diseases Society of America; American Thoracic Society. Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis 2007; 44(suppl 2):S27–S72, by permission of Oxford University Press.

    • View popup
    TABLE 4

    Indications for blood culture testing in suspected community-acquired pneumonia

    Intensive care unit admission
    Cavitary infiltrates
    Leukopenia
    Active alcohol abuse
    Chronic liver failure
    Asplenia (anatomic or functional)
    Positive pneumococcal urine antigen test
    Pleural effusion
    • Based on information in reference 1.

    • View popup
    TABLE 5

    Common organisms in community-acquired pneumonia

    Outpatient care
    Streptococcus pneumoniae
    Mycoplasma pneumoniae
    Haemophilus influenzae
    Chlamydophila pneumoniae
    Respiratory virus (influenza A and B, adenovirus, respiratory syncytial virus, parainfluenza)
    Inpatient (non-intensive care)
    S pneumoniae
    M pneumoniae
    C pneumoniae
    H influenzae
    Legionella species
    Aspiration-related oral flora
    Respiratory viruses
    Inpatient (intensive care)
    S pneumoniae
    Staphylococcus aureus
    Legionella species
    Gram-negative bacilli
    H influenzae
    • From Mandell LA, Wunderink RG, Anzueto A, et al; Infectious Diseases Society of America; American Thoracic Society. Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis 2007; 44(suppl 2):S27–S72, by permission of Oxford University Press.

    • View popup
    TABLE 6

    Initial antibiotic therapy for community-acquired pneumonia

    Outpatients without comorbiditiesa
    Amoxicillin
    Or doxycycline
    Or a macrolide
    Outpatients with comorbidities
    Combination therapy:
     Amoxicillin/clavulanate or a cephalosporin
     Plus a macrolide or doxycycline
    Or monotherapy with a fluoroquinolone
    Patients on a medical floor
    A fluoroquinolone
    Or a combination of a beta-lactam plus a macrolide
    Intensive care patients
    A beta-lactam
    Plus either a macrolide or a fluoroquinolone
    Add coverage as needed for:
    Methicillin-resistant Staphylococcus aureus (MRSA)
    Pseudomonas aeruginosa
    Influenza A
    • ↵a Comorbidities include heart, lung, liver, or renal disease, diabetes mellitus, alcoholism, malignancy, and asplenia

    • Based on information from reference 1.

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Cleveland Clinic Journal of Medicine: 87 (3)
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Community-acquired pneumonia: Strategies for triage and treatment
Anita R. Modi, Christopher S. Kovacs
Cleveland Clinic Journal of Medicine Mar 2020, 87 (3) 145-151; DOI: 10.3949/ccjm.87a.19067

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Community-acquired pneumonia: Strategies for triage and treatment
Anita R. Modi, Christopher S. Kovacs
Cleveland Clinic Journal of Medicine Mar 2020, 87 (3) 145-151; DOI: 10.3949/ccjm.87a.19067
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    • ABSTRACT
    • COMMON AND COSTLY
    • RISK-STRATIFICATION OF COMMUNITY-ACQUIRED PNEUMONIA
    • DIAGNOSIS OF COMMUNITY-ACQUIRED PNEUMONIA
    • MANAGEMENT OF COMMUNITY-ACQUIRED PNEUMONIA
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