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Review

To repeat or not to repeat? Measuring bone mineral density during anti-resorptive therapy or a drug holiday

Tayyab S. Khan, MD, Partha Sinha, MD, PhD and Harold Rosen, MD
Cleveland Clinic Journal of Medicine March 2023, 90 (3) 173-180; DOI: https://doi.org/10.3949/ccjm.90a.22071
Tayyab S. Khan
Department of Medicine, Division of Endocrinology and Metabolism, Western University, London, ON, Canada
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Partha Sinha
Department of Medicine, Division of Endocrinology and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA
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Harold Rosen
Department of Medicine, Division of Endocrinology and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA
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ABSTRACT

An initial bone mineral density (BMD) measurement is used to diagnose osteoporosis and decide whether patients need treatment, but the utility of repeating this test in those on treatment or on a drug holiday (ie, during a pause in bisphosphonate treatment) is controversial. Here, we present evidence for and against the use of BMD monitoring in patients receiving antiresorptive therapy or on a drug holiday, and give our recommendations, arguing against a one-size-fits-all approach.

  • Copyright © 2023 The Cleveland Clinic Foundation. All Rights Reserved.
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  1. Tayyab S. Khan, MD
  1. Department of Medicine, Division of Endocrinology and Metabolism, Western University, London, ON, Canada
  1. Partha Sinha, MD, PhD
  1. Department of Medicine, Division of Endocrinology and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA
  1. Harold Rosen, MD⇑
  1. Department of Medicine, Division of Endocrinology and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA
  1. Address:
    Harold Rosen, MD, Department of Medicine, Division of Endocrinology and Metabolism, Beth Israel Deaconess Medical Center, GZ-609, 330 Brookline Avenue, Boston, MA 02215; hrosen{at}bidmc.harvard.edu

ABSTRACT

An initial bone mineral density (BMD) measurement is used to diagnose osteoporosis and decide whether patients need treatment, but the utility of repeating this test in those on treatment or on a drug holiday (ie, during a pause in bisphosphonate treatment) is controversial. Here, we present evidence for and against the use of BMD monitoring in patients receiving antiresorptive therapy or on a drug holiday, and give our recommendations, arguing against a one-size-fits-all approach.

  • Copyright © 2023 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 90 (3)
Cleveland Clinic Journal of Medicine
Vol. 90, Issue 3
1 Mar 2023
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To repeat or not to repeat? Measuring bone mineral density during anti-resorptive therapy or a drug holiday
Tayyab S. Khan, Partha Sinha, Harold Rosen
Cleveland Clinic Journal of Medicine Mar 2023, 90 (3) 173-180; DOI: 10.3949/ccjm.90a.22071

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To repeat or not to repeat? Measuring bone mineral density during anti-resorptive therapy or a drug holiday
Tayyab S. Khan, Partha Sinha, Harold Rosen
Cleveland Clinic Journal of Medicine Mar 2023, 90 (3) 173-180; DOI: 10.3949/ccjm.90a.22071
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    • ABSTRACT
    • PATIENTS RECEIVING TREATMENT FOR OSTEOPOROSIS
    • PATIENTS ON A DRUG HOLIDAY
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