ABSTRACT
Postural orthostatic tachycardia syndrome (POTS)—sustained tachycardia upon standing without orthostatic hypotension—can be diagnosed clinically without an extensive diagnostic evaluation unless certain atypical features suggest an alternative diagnosis. A unifying pathophysiologic mechanism has not been identified, although several have been proposed. Similarities between POTS and various autoimmune disorders suggest an immune mechanism in a subset of patients. However, no causative antibody has been identified, and associated antibodies are rarely clinically relevant. Moreover, immunotherapies are not currently recommended for POTS, although clinical trials are underway to clarify their utility.
- Copyright © 2023 The Cleveland Clinic Foundation. All Rights Reserved.
- Albert Aboseif, DO⇑
- Address:
Albert Aboseif, DO, Department of Neurology, S9, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195; aboseia{at}ccf.org
ABSTRACT
Postural orthostatic tachycardia syndrome (POTS)—sustained tachycardia upon standing without orthostatic hypotension—can be diagnosed clinically without an extensive diagnostic evaluation unless certain atypical features suggest an alternative diagnosis. A unifying pathophysiologic mechanism has not been identified, although several have been proposed. Similarities between POTS and various autoimmune disorders suggest an immune mechanism in a subset of patients. However, no causative antibody has been identified, and associated antibodies are rarely clinically relevant. Moreover, immunotherapies are not currently recommended for POTS, although clinical trials are underway to clarify their utility.
- Copyright © 2023 The Cleveland Clinic Foundation. All Rights Reserved.
In this issue
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- Article
- ABSTRACT
- DEFINITION AND MANIFESTATIONS OF POTS
- VARIOUS MECHANISMS MAY BE INVOLVED
- BARRIERS TO A TIMELY DIAGNOSIS
- APPROACH TO POTS DIAGNOSIS AND MANAGEMENT
- RED FLAGS AND MIMICS: WHEN TO BROADEN THE DYSAUTONOMIA WORKUP
- THE ROLE OF AUTOIMMUNITY IN POTS
- POTENTIAL AUTOANTIBODY TARGETS IN POTS
- POTENTIAL USE OF IMMUNOTHERAPY IN POTS
- TAKE-HOME POINTS
- DISCLOSURES
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