Neurology

  • Unexplained pathology is not always autoimmune
    Brian F. Mandell, MD, PhD
    Cleveland Clinic Journal of Medicine July 2023, 90 (7) 395-396; DOI: https://doi.org/10.3949/ccjm.90b.07023

    Our success in understanding well-defined autoimmune diseases may make us too willing to attribute yet-unexplained conditions to autoimmunity simply because they share symptoms.

  • Autoimmunity and postural orthostatic tachycardia syndrome: Implications in diagnosis and management
    Autoimmunity and postural orthostatic tachycardia syndrome: Implications in diagnosis and management
    Albert Aboseif, DO, J. Daniel Bireley, MD, Yuebing Li, MD, PhD, David Polston, MD and Justin R. Abbatemarco, MD
    Cleveland Clinic Journal of Medicine July 2023, 90 (7) 439-447; DOI: https://doi.org/10.3949/ccjm.90a.22093

    A review of the presentation and diagnostic evaluation, including atypical features that may suggest an alternative diagnosis requiring a more extensive evaluation.

  • Guidelines for the management of trigeminal neuralgia
    Mun Seng Chong, MBBS, MD, FRCP, Anish Bahra, MBChB, MD, FRCP and Joanna M. Zakrzewska, BDS, MB BChir, MD, FDSRCS, FFDRCSI, FFPM RCA, FHEA
    Cleveland Clinic Journal of Medicine June 2023, 90 (6) 355-362; DOI: https://doi.org/10.3949/ccjm.90a.22052

    Care pathways for patients with trigeminal neuralgia vary widely. The most recent UK guidelines emphasize the need for evidence-based care plans for multidisciplinary management.

  • Reproductive issues and multiple sclerosis: 20 questions
    Alise K. Carlson, MD, Daniel Ontaneda, MD, PhD, Mary R. Rensel, MD, Jeffrey A. Cohen, MD and Amy Kunchok, MD
    Cleveland Clinic Journal of Medicine April 2023, 90 (4) 235-243; DOI: https://doi.org/10.3949/ccjm.90a.22066

    The authors offer answers to frequently asked questions about the management of MS during pregnancy planning, pregnancy, and the postpartum period.

  • Myasthenia gravis: Frequently asked questions
    John A. Morren, MD and Yuebing Li, MD, PhD
    Cleveland Clinic Journal of Medicine February 2023, 90 (2) 103-113; DOI: https://doi.org/10.3949/ccjm.90a.22017

    Who is at risk? Which tests should be ordered? How does the disease course affect management decisions? What instructions should you give patients? And other questions.

  • Myasthenia gravis: An update for internists
    Brian F. Mandell, MD, PhD
    Cleveland Clinic Journal of Medicine February 2023, 90 (2) 72-73; DOI: https://doi.org/10.3949/ccjm.90b.02023

    Recognizing the spectrum of the disease in patients’ complaints enhances our clinical reasoning skills when faced with the extremely commonly expressed symptom of “fatigue.”

  • Our Peer-Reviewers For 2022
    Brian F. Mandell, MD, PhD
    Cleveland Clinic Journal of Medicine February 2023, 90 (2) 78;
  • What are the treatment options for myasthenia gravis if first-line agents fail?
    Christopher Zust, MD and John A. Morren, MD
    Cleveland Clinic Journal of Medicine February 2023, 90 (2) 81-84; DOI: https://doi.org/10.3949/ccjm.90a.22022

    From 5% to 20% of patients may have a suboptimal response or prohibitive adverse effects over a period of a few weeks to 3 months.

  • Which patients hospitalized with alcohol withdrawal syndrome should receive high-dose parenteral thiamine?
    Rahul B. Ganatra, MD, MPH, Anthony C. Breu, MD and Matthew V. Ronan, MD
    Cleveland Clinic Journal of Medicine January 2023, 90 (1) 22-25; DOI: https://doi.org/10.3949/ccjm.90a.22026

    The authors briefly outline risk factors for Wernicke encephalopathy and when high-dose parenteral thiamine is indicated.

  • Central vision loss in a 44-year-old woman
    Walker M. Schmidt, BS, Nirosha D. Perera, MD, Blake H. Fortes, MD, Benjamin A. Nelson, MD, Wendy M. Smith, MD and Hannah C. Nordhues, MD
    Cleveland Clinic Journal of Medicine January 2023, 90 (1) 35-41; DOI: https://doi.org/10.3949/ccjm.90a.22038

    The patient had a wide range of symptoms and comorbidities, resulting in a complicated differential diagnosis. Careful evaluation eventually led to a focus on sexually transmitted infection.

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