Neurology

  • A young woman with Kallmann syndrome and acute neurologic symptoms
    A young woman with Kallmann syndrome and acute neurologic symptoms
    Jumaina F. Ali, MBChB, Adhithya Sankar, MBChB, PhD, Mohammed S. O. Ahmed, MBBS, MSc, Mark Woodward, BSc (Hons), MBChB and Akheel A. Syed, MBBS, PhD
    Cleveland Clinic Journal of Medicine January 2026, 93 (1) 29-34; DOI: https://doi.org/10.3949/ccjm.93a.25010

    Diagnoses considered on initial presentation included conditions that present with stroke-like symptoms such as seizure, hemiplegic migraine, transient ischemic attack, and brain tumor.

  • Trident sign in osmotic demyelination syndrome
    Erin Equinozzi, MSc, Clement D. Lee, MD, MSc and Pamela Schaefer, MD
    Cleveland Clinic Journal of Medicine December 2025, 92 (12) 732-733; DOI: https://doi.org/10.3949/ccjm.92a.24080

    Brain magnetic resonance imaging showed a confluent trident-shaped lesion in the central pons 1 week after correction of the patient’s chronic hyponatremia.

  • MDA5 dermatomyositis: Unveiling a potentially life-threatening disease
    Soumya Chatterjee, MD, MS
    Cleveland Clinic Journal of Medicine October 2025, 92 (10) 627-637; DOI: https://doi.org/10.3949/ccjm.92a.25018

    Timely diagnosis and initiation of aggressive immunosuppressive therapy are key to improving the 40% overall mortality rate in patients with MDA5 dermatomyositis.

  • Cerebrovascular complications in infective endocarditis: Challenges and considerations in management
    Cerebrovascular complications in infective endocarditis: Challenges and considerations in management
    Vikyath Satish, MD, Maisha Maliha, MD, Abhyuday Chauhan, MD, Nieves del Mar Morales-Gomez, MD, Safwan Gaznabi, MD, Daniel Lorenzatti, MD, Justin Johannesen, MD, Carlos A. Gongora, MD, Annalisa Filtz, MD, Mario J. Garcia, MD, Leandro Slipczuk, MD, PhD and Aldo L. Schenone, MD
    Cleveland Clinic Journal of Medicine August 2025, 92 (8) 491-501; DOI: https://doi.org/10.3949/ccjm.92a.24087

    Although the cerebrovascular complications of infective endocarditis such as ischemic strokes and intracranial hemorrhages are common and serious, data remain scarce regarding how best to prevent, predict, and manage them.

  • Unexplained pathology is not always autoimmune
    Brian F. Mandell, MD, PhD
    Cleveland Clinic Journal of Medicine July 2023, 90 (7) 395-396; DOI: https://doi.org/10.3949/ccjm.90b.07023

    Our success in understanding well-defined autoimmune diseases may make us too willing to attribute yet-unexplained conditions to autoimmunity simply because they share symptoms.

  • Autoimmunity and postural orthostatic tachycardia syndrome: Implications in diagnosis and management
    Autoimmunity and postural orthostatic tachycardia syndrome: Implications in diagnosis and management
    Albert Aboseif, DO, J. Daniel Bireley, MD, Yuebing Li, MD, PhD, David Polston, MD and Justin R. Abbatemarco, MD
    Cleveland Clinic Journal of Medicine July 2023, 90 (7) 439-447; DOI: https://doi.org/10.3949/ccjm.90a.22093

    A review of the presentation and diagnostic evaluation, including atypical features that may suggest an alternative diagnosis requiring a more extensive evaluation.

  • Guidelines for the management of trigeminal neuralgia
    Mun Seng Chong, MBBS, MD, FRCP, Anish Bahra, MBChB, MD, FRCP and Joanna M. Zakrzewska, BDS, MB BChir, MD, FDSRCS, FFDRCSI, FFPM RCA, FHEA
    Cleveland Clinic Journal of Medicine June 2023, 90 (6) 355-362; DOI: https://doi.org/10.3949/ccjm.90a.22052

    Care pathways for patients with trigeminal neuralgia vary widely. The most recent UK guidelines emphasize the need for evidence-based care plans for multidisciplinary management.

  • Reproductive issues and multiple sclerosis: 20 questions
    Alise K. Carlson, MD, Daniel Ontaneda, MD, PhD, Mary R. Rensel, MD, Jeffrey A. Cohen, MD and Amy Kunchok, MD
    Cleveland Clinic Journal of Medicine April 2023, 90 (4) 235-243; DOI: https://doi.org/10.3949/ccjm.90a.22066

    The authors offer answers to frequently asked questions about the management of MS during pregnancy planning, pregnancy, and the postpartum period.

  • Myasthenia gravis: Frequently asked questions
    John A. Morren, MD and Yuebing Li, MD, PhD
    Cleveland Clinic Journal of Medicine February 2023, 90 (2) 103-113; DOI: https://doi.org/10.3949/ccjm.90a.22017
  • Myasthenia gravis: An update for internists
    Brian F. Mandell, MD, PhD
    Cleveland Clinic Journal of Medicine February 2023, 90 (2) 72-73; DOI: https://doi.org/10.3949/ccjm.90b.02023

    Recognizing the spectrum of the disease in patients’ complaints enhances our clinical reasoning skills when faced with the extremely commonly expressed symptom of “fatigue.”

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