Table of Contents
From the Editor
- We need your help
If your copy of the Journal has a postcard on the cover, please sign it and drop it in the mail—it could save us a lot of money.
The Clinical Picture
Cancer Diagnosis and Management
- Malignant melanoma: Treatments emerging, but early detection is still key
Interferon alfa-2b can increase disease-free survival in malignant melanoma, but we can have far more impact by detecting this disease earlier and by teaching patients how to recognize and possibly avoid it.
1-Minute Consult
Why shouldn’t we use warfarin alone to treat acute venous thrombosis?Heparins produce desired levels of anticoagulation within hours, whereas warfarin takes at least 4 days.
Im Board Review
Interpreting Key Trials
- GUSTO V: Combination drug treatment of acute myocardial infarction
The combination of abciximab in full doses and reteplase in half doses was not superior to full-dose reteplase alone, but it was “not inferior” either.
Current Drug Therapy
- Aromatase inhibitors in breast cancer: Current and evolving roles
Aromatase inhibitors are finding new uses. Already established for treating metastatic breast cancer in postmenopausal women, they are gaining acceptance as adjuvant treatment as well.
Medical Grand Rounds
- Acute renal failure in hospitalized patients
Acute renal failure demands a logical approach to its prevention and early diagnosis.
Commentary
The results of GUSTO V were equivocal and should not lead physicians to change how they treat myocardial infarction.