The homocysteine hypothesis: Still relevant to the prevention and treatment of cardiovascular disease?

Joellyn M. Abraham; Leslie Cho

doi:10.3949/ccjm.77a.10036

Review

The homocysteine hypothesis: Still relevant to the prevention and treatment of cardiovascular disease?

Joellyn M. Abraham, MD and Leslie Cho, MD

Cleveland Clinic Journal of Medicine December 2010, 77 (12) 911-918; DOI: https://doi.org/10.3949/ccjm.77a.10036

Joellyn M. Abraham

Cardiovascular Medicine, Cleveland Clinic

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Leslie Cho

Section Head, Preventive Cardiology and Rehabilitation, and Director, Women’s Cardiovascular Center, Cleveland Clinic

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For correspondence: [email protected]

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ABSTRACT

Although evidence suggests that the homocysteine hypothesis is still relevant as a predictor of cardiovascular risk, we cannot conclude that measuring the homocysteine level is useful in guiding treatment. Furthermore, studies of primary and secondary prevention show no evidence that taking folic acid or other B vitamins lowers the risk of cardiovascular events.

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Cleveland Clinic Journal of Medicine

Vol. 77, Issue 12

1 Dec 2010

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