Table of Contents
From the Editor
- Why is fixing the plumbing so difficult?
For carotid stenosis, a catheter-based procedure would seem safer than endarterectomy, but reality is not always so simple.
The Clinical Picture
- Cornflake-like scales on the ankles and feet
An 81-year-old woman presents with slowly growing, asymptomatic lesions on both feet and ankles. Which test should be ordered to establish the diagnosis?
Current Drug Therapy
- MAO inhibitors: Risks, benefits, and lore
Monoamine oxidase inhibitors were the first antidepressants introduced. Interest in their use is reviving.
1-Minute Consult
- Should alpha-blockers ever be used as antihypertensive drugs?
They are not first-line drugs, but they can be second-line or third-line add-on drugs if blood pressure is not under control.
Interpreting Key Trials
- Understanding the CREST results
For patients with carotid artery stenosis, percutaneous intervention with stenting is as good as surgery—with some qualifications.
Medical Grand Rounds
- Vitamin D and the heart: Why we need large-scale clinical trials
Despite enthusiasm for vitamin D, no large-scale primary prevention trial has used cardiovascular disease or cancer as a prespecified primary outcome.
Review
- The homocysteine hypothesis: Still relevant to the prevention and treatment of cardiovascular disease?
Elevated homocysteine is a risk factor, and vitamins lower homocysteine levels. But does vitamin supplementation prevent cardiovascular events?
- Managing gout: How is it different in patients with chronic kidney disease?
The goals are the same, but the choice and dosage of drugs may need to be modified.
Departments
- Glucocorticoid-induced osteoporosis (August 2010)
Readers comment on nutritional supplementation after bariatric surgery (July 2010) and on glucocorticoid-induced osteoporosis (August 2010).
- Bariatric surgery, vitamin C, and kidney stones (July 2010)
Readers comment on nutritional supplementation after bariatric surgery (July 2010) and on glucocorticoid-induced osteoporosis (August 2010).