Article Figures & Data
Tables
Characteristic Chronic Accelerated Blastic Blasts (%) 1–15 ≥ 15 ≥ 30 Basophils (%) Increased ≥ 20 Any number Platelets Increased or normal Increased or decreased Decreased Bone marrow Myeloid hyperplasia Duration 4–6 years Up to 1 year 3–6 months Based on information in references 3 and 4.
Stage Simplified 3-stage system Clinical features Median survival (years) 0 Low risk Lymphocytosis in blood and marrow only > 10 I Intermediate risk Lymphadenopathy 7 II Splenomegaly with or without hepatomegaly III High risk Anemia 1.5–4 IV Thrombocytopenia Based on information in reference 19.
Constitutional symptoms attributable to the disease Progressive marrow failure Autoimmune anemia or thrombocytopenia poorly responsive to corticosteroids Massive or progressive splenomegaly Massive or progressive lymphadenopathy Rapid lymphocyte doubling time Based on information in reference 30.