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Im Board Review

Fever after recent travel

Habib Rehman, MBBS, FRCPC, FRCPI, FRCP (GLAS), FACP
Cleveland Clinic Journal of Medicine November 2017, 84 (11) 840-846; DOI: https://doi.org/10.3949/ccjm.84a.16046
Gregory W. Rutecki
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Habib Rehman
Clinical Associate Professor, Department of Medicine, Regina Qu’Appelle Health Region, Regina, SK, Canada
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  • For correspondence: habib31@sasktel.net
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  • FIGURE 1
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    FIGURE 1

    At presentation, the patient had a sparse, erythematous, macular, nonblanching rash on the lower and upper limbs.

  • FIGURE 2
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    FIGURE 2

    Repeat chest radiography showed a new right basilar consolidation with a small effusion (arrow).

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    TABLE 1

    Laboratory testing results

    Current admissionRecent admissionReference range
    White blood cell count10.08.84.0–10.0 × 109/L
    Lymphocytes6.1aNot available1.2–3.4 × 109/L
    Hemoglobin13.613.214.0–18.0 g/dL
    Platelets87136150–400 × 109/L
    Albumin472835–50 g/L
    Total bilirubin48202–20 μmol/L
    Alkaline phosphatase13731440–135 U/L
    Alanine aminotransferase221939–69 U/L
    Aspartate aminotransferase721305–45 U/L
    Erythrocyte sedimentation rateNot available290–20 mm/hour
    • ↵a Abnormal values are shown in bold.

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    TABLE 2

    Diagnostic tests in endemic mycosis

    HistoplasmosisCoccidioidomycosisBlastomycosis
    CulturePositive in 75%High yieldHigh yield
    Urine antigen detection75%–90% sensitivity
    Cross-reactivity with blastomycosis, paracoccidioidomycosis
    Sensitivity and specificity not known93% sensitivity
    95.6% cross-reactivity with histoplasmosis
    Serologic testingHigh sensitivity
    Cross-reactivity with blastomycosis and coccidioidomycosis
    High sensitivity and specificityNot useful
    Poor sensitivity
    Significant cross-reactivity with histoplasmosis
    Nucleic acid testingUncertain valueUnder development86% sensitivity
    99% specificity
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Cleveland Clinic Journal of Medicine: 84 (11)
Cleveland Clinic Journal of Medicine
Vol. 84, Issue 11
1 Nov 2017
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Fever after recent travel
Habib Rehman
Cleveland Clinic Journal of Medicine Nov 2017, 84 (11) 840-846; DOI: 10.3949/ccjm.84a.16046

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Fever after recent travel
Habib Rehman
Cleveland Clinic Journal of Medicine Nov 2017, 84 (11) 840-846; DOI: 10.3949/ccjm.84a.16046
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  • Article
    • INITIAL EVALUATION
    • DIFFERENTIAL DIAGNOSIS
    • TUBERCULOSIS IN PATIENTS ON TNF-ALPHA ANTAGONISTS
    • COCCIDIOIDOMYCOSIS
    • BLASTOMYCOSIS
    • NARROWING THE DIFFERENTIAL
    • HISTOPLASMOSIS
    • TESTING FOR HISTOPLASMOSIS
    • TREATMENT
    • COMPLICATIONS OF HISTOPLASMOSIS
    • CASE CONCLUSION
    • REFERENCES
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