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Altered mental status Focal neurologic deficits Seizures within 1 week Papilledema Immunodeficiency History of central nervous system disease Age ≥ 60 High clinical suspicion for subarachnoid hemorrhage Skin infection at the puncture site Spine infection at the puncture site Thrombocytopenia (platelet count < 50 × 109/L) or use of antithrombotic agents other than aspirin Coagulopathy (international normalized ratio > 1.4) or use of anticoagulants