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Review

Chronic constipation: Update on management

Umar Hayat, MD, Mohannad Dugum, MD and Samita Garg, MD
Cleveland Clinic Journal of Medicine May 2017, 84 (5) 397-408; DOI: https://doi.org/10.3949/ccjm.84a.15141
Umar Hayat
Department of Internal Medicine, Medicine Institute, Cleveland Clinic
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Mohannad Dugum
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  • For correspondence: [email protected]
Samita Garg
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    FIGURE 1

    Diagnosis and management of chronic constipation.

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    TABLE 1

    Causes of secondary constipation

    Neurologic and motility disorders
    Amyloidosis
    Diabetes
    Hirschsprung disease
    Hypothyroidism
    Multiple sclerosis
    Parkinson disease
    Spinal cord injury
    Spinal or ganglionic tumors
    Stroke
    Diseases in which treatment can cause constipation
    Bipolar disorder
    Chronic pain
    Depression
    Parkinson disease
    Schizophrenia
    Medications
    Anticholinergics
    Anticonvulsants
    Antidepressants
    Antipsychotics
    Antispasmodics
    Calcium channel blockers
    Opioids
    Other causes
    Chagas disease
    Conversion disorder
    Decreased fluid intake
    Hypercalcemia
    Hyperparathyroidism
    Low-fiber diet
    Mechanical obstruction
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    TABLE 2

    Nonpharmacologic management of chronic constipation

    Increase physical activity (most beneficial in early orning)
    Toilet training. Instruct patients to:
    Not ignore urges to defecate
    Use correct posture, ie, “brace-pump” technique: sit on the toilet and lean forward, with knees higher than hips and with feet supported on a step to straighten the anorectal angle
    Do deep-relaxation techniques while defecating
    Avoid straining when passing stool
    Not stay on the toilet for more than 5–10 minutes
    Dietary changes
    Drink a hot caffeinated beverage after waking up
    Eat breakfast within 1 hour of waking up
    Increase fluid intake to 1.5–2 L daily
    Increase dietary fiber to 25–30 g daily; do this slowly to avoid abdominal cramps and bloating
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    TABLE 3

    Agents for treating chronic constipation

    Bulk-forming laxatives
    Insoluble fiber (bran)
    Soluble fiber (psyllium, methylcellulose, calcium polycarbophil)
    Osmotic laxatives
    Polyethylene glycol, lactulose, sorbitol, magnesium hydroxide, magnesium citrate, sodium phosphate enemas
    Stool softeners
    Docusate
    Stimulant laxatives
    Bisacodyl, anthraquinones, glycerin suppository
    Intestinal secretagogues
    Linaclotide, lubiprostone
    Opioid receptor antagonists
    Methylnaltrexone, neloxegol
    AGENTS IN DEVELOPMENT
    Selective serotonin (5-HT4) agonists
    Naronapride, prucalopride, velusetrag
    Ileal bile acid transporter inhibitors
    Elboxibat
    Intestinal secretagogues
    Plecanatide
    NHE3 sodium transporter inhibitors
    Tenapanor
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Cleveland Clinic Journal of Medicine: 84 (5)
Cleveland Clinic Journal of Medicine
Vol. 84, Issue 5
1 May 2017
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Chronic constipation: Update on management
Umar Hayat, Mohannad Dugum, Samita Garg
Cleveland Clinic Journal of Medicine May 2017, 84 (5) 397-408; DOI: 10.3949/ccjm.84a.15141

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Chronic constipation: Update on management
Umar Hayat, Mohannad Dugum, Samita Garg
Cleveland Clinic Journal of Medicine May 2017, 84 (5) 397-408; DOI: 10.3949/ccjm.84a.15141
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Jump to section

  • Article
    • ABSTRACT
    • THE EPIDEMIOLOGY OF CONSTIPATION
    • DEFECATION IS COMPLEX
    • PRIMARY CONSTIPATION DISORDERS
    • SECONDARY CONSTIPATION
    • EVALUATION OF CONSTIPATION
    • TRADITIONAL TREATMENTS STILL THE MAINSTAY
    • LAXATIVES
    • STOOL SOFTENERS: LITTLE EVIDENCE
    • INTESTINAL SECRETAGOGUES
    • SEROTONIN RECEPTOR AGONISTS
    • BILE SALT ABSORPTION INHIBITORS
    • MANAGING OPIOID-INDUCED CONSTIPATION
    • CONSTIPATION-PREDOMINANT IRRITABLE BOWEL SYNDROME
    • DYSSYNERGIC DEFECATION AND ANORECTAL BIOFEEDBACK
    • SURGERY FOR CHRONIC CONSTIPATION
    • REFERENCES
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