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Cleveland Clinic Journal of Medicine
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Cleveland Clinic Journal of Medicine

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Pain

  • You have access
    A new direction in pain management?
    Brian F. Mandell, MD, PhD
    Cleveland Clinic Journal of Medicine February 2026, 93 (2) 67-68; DOI: https://doi.org/10.3949/ccjm.93b.02026

    It would be nice to have a treatment option for pain that is less limited by side effects, cognitive dysfunction, addiction potential, and red tape.

  • You have access
    Suzetrigine: A novel nonopioid systemic analgesic
    Anthony E. Divito, MD, Matthew Sharobeem, DO, Gausan R. Bajracharya, MD and Basem B. Abdelmalak, MD
    Cleveland Clinic Journal of Medicine February 2026, 93 (2) 94-98; DOI: https://doi.org/10.3949/ccjm.93a.25087

    The systemic sodium channel blocker suzetrigine may serve as another option for multimodal postoperative analgesia regimens and for managing acute nonsurgical pain.

  • You have access
    Chronic ocular pain
    Radhika S. Amin, Eliot N. Haddad and Rony R. Sayegh, MD
    Cleveland Clinic Journal of Medicine November 2025, 92 (11) 652; DOI: https://doi.org/10.3949/ccjm.92c.11003
  • You have access
    Nociplastic pain: A practical guide to chronic pain management in the primary care setting
    Rupak Thapa, MD and Dennis Ang, MD
    Cleveland Clinic Journal of Medicine April 2025, 92 (4) 236-247; DOI: https://doi.org/10.3949/ccjm.92a.24101

    Nociplastic pain is characterized by amplification of pain transmission and pain perception and does not involve visible tissue injury or damage, which makes it difficult to understand and manage.

  • You have access
    A practical guide for buprenorphine initiation in the primary care setting
    Roberto León-Barriera, MD, Samantha Jayne Zwiebel, MD, MA and Vania Modesto-Lowe, MD, MPH
    Cleveland Clinic Journal of Medicine September 2023, 90 (9) 557-564; DOI: https://doi.org/10.3949/ccjm.90a.23022

    The authors review changes in prescribing laws and outline buprenorphine induction protocols that can be adopted in the primary care setting.

  • You have access
    Guidelines for the management of trigeminal neuralgia
    Mun Seng Chong, MBBS, MD, FRCP, Anish Bahra, MBChB, MD, FRCP and Joanna M. Zakrzewska, BDS, MB BChir, MD, FDSRCS, FFDRCSI, FFPM RCA, FHEA
    Cleveland Clinic Journal of Medicine June 2023, 90 (6) 355-362; DOI: https://doi.org/10.3949/ccjm.90a.22052

    Care pathways for patients with trigeminal neuralgia vary widely. The most recent UK guidelines emphasize the need for evidence-based care plans for multidisciplinary management.

  • You have access
    Chronic centralized pain syndromes: A rheumatologist’s perspective
    Brian F. Mandell, MD, PhD
    Cleveland Clinic Journal of Medicine April 2023, 90 (4) 201-202; DOI: https://doi.org/10.3949/ccjm.90b.04023

    Centralized pain syndromes are vexing for patients and clinicians. In this issue, Volcheck and colleagues present a framework for understanding chronic centralized pain and for developing an actionable treatment plan for patients.

  • You have access
    Central sensitization, chronic pain, and other symptoms: Better understanding, better management
    Mary M. Volcheck, MSN, RN, Stephanie M. Graham, RN, Kevin C. Fleming, MD, Arya B. Mohabbat, MD and Connie A. Luedtke, RN, PMGT-BC
    Cleveland Clinic Journal of Medicine April 2023, 90 (4) 245-254; DOI: https://doi.org/10.3949/ccjm.90a.22019

    Clinicians have a pivotal role by providing patient education, which can affect perception, management, functional status, and quality of life.

  • You have access
    How do I interpret and use quantitative buprenorphine and norbuprenorphine urine levels?
    Richard C. Waters, MD, MSc and Matthew Perez, MD
    Cleveland Clinic Journal of Medicine October 2022, 89 (10) 557-560; DOI: https://doi.org/10.3949/ccjm.89a.21019

    Confirmatory testing of urine samples can be useful in outpatient settings where buprenorphine dosing is not directly observed. But retaining and engaging the patient in effective treatment should be the ultimate goals of testing.

  • You have access
    Psychogenic nonepileptic seizure: An empathetic, practical approach
    Becky Bikat S. Tilahun, PhD and Jocelyn F. Bautista, MD
    Cleveland Clinic Journal of Medicine May 2022, 89 (5) 252-259; DOI: https://doi.org/10.3949/ccjm.89a.21109

    Barriers to care include clinician misperceptions, lack of acceptance of the diagnosis, poor patient engagement with treatment, and lack of access to care.

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