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Symptoms to Diagnosis

Rapidly progressive pleural effusion

Zaid Zoumot, MBBS, Ali S. Wahla, MBBS and Samar Farha, MD
Cleveland Clinic Journal of Medicine January 2019, 86 (1) 21-27; DOI: https://doi.org/10.3949/ccjm.86a.18067
Gregory W. Rutecki
Respiratory and Critical Care Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE
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Zaid Zoumot
Respiratory and Critical Care Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE
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Ali S. Wahla
Respiratory and Critical Care Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE
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Samar Farha
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  • For correspondence: [email protected]
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    Figure 1

    Chest radiography in the emergency department (A) showed a mild left-sided pleural reaction (arrow). Computed tomography (B) showed a mild pleural reaction (arrow) and parenchymal atelectatic and fi brotic changes.

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    Figure 2

    Chest radiography 5 days after the emergency department presentation showed development of a left-sided pleural effusion.

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    Figure 3

    Complete opacification of the left hemothorax on chest radiography (A) and massive pleural effusion causing mediastinal shift to the right on computed tomography (B).

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    Figure 4

    Computed tomography 2 days after initial chest tube placement showed a non-communicating apical pocket.

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    TABLE 1

    Prognostic assessment of pleural effusion: the American College of Chest Physicians guidelines

    Pleural space anatomyPleural fluid bacteriologyPleural fluid chemistryCategoryRisk of poor outcomeDrainage
    Minimal, free-flowing effusion (< 10 mm on lateral decubitus image)andCulture and Gram stain results unknownandpH unknown1Very lowNo
    Small to moderate free- flowing effusion (> 10 mm and < 1/2 hemithorax)andNegative culture and Gram stainandpH ≥ 7.202LowNo
    Large, free-flowing effusion (≥ 1/2 hemothorax), loculated effusion, or effusion with thickened parietal pleuraorPositive culture and Gram stainorpH < 7.203ModerateYes
    Pus4HighYes
    • Reprinted from Coulice et al,1 with permission from Elsevier; www.sciencedirect.com/science/journal/chest.

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    TABLE 2

    Our patient’s pleural fluid analysis

    Test Pleural fluid analysisValue
    Glucose0.8 mmol/L
    Total protein53 g/L
    Lactate dehydrogenase687 IU/L
    Triglyceride0.75 mmol/L
    Cholesterol2.41 mmol/L
    pH7.00
    Gram stainNo organism seen
    Culture (bacterial, fungal, acid-fast bacilli)No growth
    Serum levels
    Lactate dehydrogenase228 IU/L
    Protein71 g/L
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    TABLE 3

    Transudate or exudate? The Light criteria

    The fluid is defined as an exudate if at least 1 of the following 3 criteria is met:
    • Ratio of pleural fluid protein to serum protein > 0.5

    • Ratio of pleural fluid lactate dehydrogenase (LDH) to serum LDH > 0.6

    • Pleural fluid LDH more than 2/3 the upper limits of the laboratory normal serum LDH

    • Information from Light et al, reference 7.

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Cleveland Clinic Journal of Medicine: 86 (1)
Cleveland Clinic Journal of Medicine
Vol. 86, Issue 1
1 Jan 2019
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Rapidly progressive pleural effusion
Zaid Zoumot, Ali S. Wahla, Samar Farha
Cleveland Clinic Journal of Medicine Jan 2019, 86 (1) 21-27; DOI: 10.3949/ccjm.86a.18067

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Rapidly progressive pleural effusion
Zaid Zoumot, Ali S. Wahla, Samar Farha
Cleveland Clinic Journal of Medicine Jan 2019, 86 (1) 21-27; DOI: 10.3949/ccjm.86a.18067
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  • Article
    • DIFFERENTIAL DIAGNOSIS OF PLEURITIC CHEST PAIN
    • CLINIC VISIT 5 DAYS LATER
    • FURTHER TREATMENT
    • 5 DAYS LATER, THE EFFUSION HAD BECOME MASSIVE
    • RAPIDLY PROGRESSIVE PLEURAL EFFUSIONS
    • CASE CONTINUED
    • LOCULATED EMPYEMA: MANAGEMENT
    • MANAGEMENT OF PARAPNEUMONIC PLEURAL EFFUSION IN ADULTS
    • THE PATIENT RECOVERED
    • REFERENCES
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