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Review

Current management of Barrett esophagus and esophageal adenocarcinoma

Tavankit Singh, MD, Vedha Sanghi, MD and Prashanthi N. Thota, MD, FACG
Cleveland Clinic Journal of Medicine November 2019, 86 (11) 724-732; DOI: https://doi.org/10.3949/ccjm.86a.18106
Tavankit Singh
Department of Gastroenterology and Hepatology, Cleveland Clinic
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Vedha Sanghi
Department of Internal Medicine, Cleveland Clinic; Clinical Instructor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
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Prashanthi N. Thota
Medical Director, Esophageal Center, Digestive Disease and Surgery Institute, Cleveland Clinic; Clinical Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
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    Figure 1

    Four-quadrant biopsies are taken every 2 cm, plus at any mucosal irregularities in salmon-colored mucosa above the gastroesophageal junction.

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    Figure 2

    A: Endoscopic picture of Barrett esophagus with arrow pointing to nodule. B: After endoscopic mucosal resection of nodule. C: Barrett esophagus before radiofrequency ablation. D: Barrett esophagus after ablation.

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    TABLE 1

    Surveillance guidelines for Barrett esophagusa

    Nondysplastic Barrett esophagus
    AGA, ACG, and ASGE recommend surveillance every 3–5 years
    ‘Indefinite for dysplasia’
    AGA: no recommendation
    ACG: repeat esophagogastroduodenoscopy (EGD) after 3–6 months of proton pump inhibitor (PPI) therapy; if repeat EGD indicates “indefinite for dysplasia,” then surveillance every 12 months
    ASGE: additional pathology review, PPI dose escalation, and repeat
    EGD with biopsy
    Low-grade dysplasia
    AGA: surveillance every 6–12 months
    ACG: either endoscopic eradication therapy for confirmed low-grade dysplasia for patients without a life-limiting comorbidity, or surveillance every 12 months
    ASGE: repeat EGD in 6 months to confirm low-grade dysplasia, then surveillance every year, with eradication therapy in select patients
    High-grade dysplasia
    AGA: eradication therapy or surveillance every 3 months
    ACG: eradication therapy for confirmed high-grade dysplasia in patients without a life-limiting comorbidity
    ASGE: eradication therapy or surveillance every 3 months
    • ↵a All guidelines recommend confirmation of dysplasia by an expert gastrointestinal pathologist.

    • ACG = American College of Gastroenterology4; AGA = American Gastroenterological Association24; ASGE = American Society for Gastrointestinal Endoscopy23

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Cleveland Clinic Journal of Medicine: 86 (11)
Cleveland Clinic Journal of Medicine
Vol. 86, Issue 11
1 Nov 2019
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Current management of Barrett esophagus and esophageal adenocarcinoma
Tavankit Singh, Vedha Sanghi, Prashanthi N. Thota
Cleveland Clinic Journal of Medicine Nov 2019, 86 (11) 724-732; DOI: 10.3949/ccjm.86a.18106

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Current management of Barrett esophagus and esophageal adenocarcinoma
Tavankit Singh, Vedha Sanghi, Prashanthi N. Thota
Cleveland Clinic Journal of Medicine Nov 2019, 86 (11) 724-732; DOI: 10.3949/ccjm.86a.18106
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Jump to section

  • Article
    • ABSTRACT
    • SCOPE OF THE PROBLEM
    • GASTROESOPHAGEAL REFLUX DISEASE IS A RISK FACTOR FOR CANCER
    • RISK FACTORS FOR BARRETT ESOPHAGUS
    • SCREENING GUIDELINES AND DRAWBACKS
    • SURVEILLANCE: WHAT’S INVOLVED, WHAT’S AVAILABLE
    • MANAGEMENT OF NONDYSPLASTIC BARRETT ESOPHAGUS
    • DOES CHEMOPREVENTION HAVE A ROLE?
    • INDEFINITE DYSPLASIA
    • ENDOSCOPIC ERADICATION: AN OVERVIEW
    • LOW-GRADE DYSPLASIA: RECOMMENDED MANAGEMENT
    • HIGH-GRADE DYSPLASIA: RECOMMENDED MANAGEMENT
    • EARLY ESOPHAGEAL ADENOCARCINOMA: RECOMMENDED MANAGEMENT
    • POSTABLATION MANAGEMENT
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