Current Drug Therapy

Prescribing testosterone and DHEA: The role of androgens in women

Taryn Smith, MD, NCMP and Pelin Batur, MD, FACP, NCMP
Cleveland Clinic Journal of Medicine January 2021, 88 (1) 35-43; DOI: https://doi.org/10.3949/ccjm.88a.20030

Article Figures & Data

Tables

  • TABLE 1

    Conditions that affect circulating levels of sex hormone-binding globulin (SHBG)

    Decrease SHBG
    (increase free [active] testosterone)
    Obesity
    Exogenous androgen therapy
    Insulin
    Glucocorticoids
    Increase SHBG
    (decrease free [active] testosterone)
    Pregnancy
    Exogenous estrogen therapy
    Liver cirrhosis
    Hyperthyroidism
  • TABLE 2

    Conditions that cause a low androgen state in women

    Decreased ovarian androgen production
    Chemotherapy
    Radiation
    Ovarian failure or insufficiency
    Oophorectomy
    Decreased adrenal androgen production
    Adrenal insufficiency
    Hypothalamic-pituitary axis
    Malnutrition
    Anorexia
    Hypopituitarism
    Medications
    Corticosteroids
    Hormonal contraceptives
    Antiandrogenic agents
    Oral estrogen therapy
    Opioids
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