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Cleveland Clinic Journal of Medicine
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Cleveland Clinic Journal of Medicine

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Mental Health

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    Updated guidelines for pharmacologic treatment of perinatal depression: Understanding medication options
    Rebeca Ortiz Worthington, MD, MS, CLC, Zehra Aftab, MD, Nicole Leong, MD, MS and Jason Alexander, MD
    Cleveland Clinic Journal of Medicine April 2026, 93 (4) 201-205; DOI: https://doi.org/10.3949/ccjm.93a.25052

    In a guideline update, the American College of Obstetricians and Gynecologists now recommends using pharmacotherapy to treat perinatal depression, with selective serotonin reuptake inhibitors as first-line medications.

  • You have access
    Treating perinatal mood and anxiety disorders: A call to action
    Lulu Zhao, MD
    Cleveland Clinic Journal of Medicine April 2026, 93 (4) 207-209; DOI: https://doi.org/10.3949/ccjm.93a.26002

    Perinatal mood and anxiety disorders remain untreated in 3 of 4 affected individuals giving birth.

  • You have access
    Chronic ocular pain
    Radhika S. Amin, Eliot N. Haddad and Rony R. Sayegh, MD
    Cleveland Clinic Journal of Medicine November 2025, 92 (11) 652; DOI: https://doi.org/10.3949/ccjm.92c.11003
  • You have access
    Flexibility is warranted in applying prescribing guidelines
    Brian F. Mandell, MD, PhD
    Cleveland Clinic Journal of Medicine September 2025, 92 (9) 520-521; DOI: https://doi.org/10.3949/ccjm.92b.09025

    Discontinuation of benzodiazepines in chronic users may be associated with a small increase in mortality and a higher risk of adverse events, especially in the short term after cessation.

  • You have access
    Benzodiazepines: Caught between patient needs and guidelines
    Jasleen Kaur, MD, Vania Modesto-Lowe, MD, MPH and Margaret M. Chaplin, MD
    Cleveland Clinic Journal of Medicine September 2025, 92 (9) 531-535; DOI: https://doi.org/10.3949/ccjm.92a.25019

    Negative sentiment about benzodiazepines has intensified in recent years, and there is increasing emphasis on deprescribing even for people who have had no ill effects from them.

  • You have access
    Recreational cannabis legalization: Potential implications for individual and community health
    Taseen Alam, BA, Connor Riegal, BS, Natalie Saadeh, MD, Fernanda Gushken, MD, MS, Hannah Snyder, MD, Brenden Jenks, MD and Akhil Anand, MD
    Cleveland Clinic Journal of Medicine July 2025, 92 (7) 407-413; DOI: https://doi.org/10.3949/ccjm.92a.24086

    The authors discuss evidence on the effects of legalized recreational cannabis on overall cannabis consumption, crime, traffic safety, and individual and community health.

  • You have access
    Psychedelics in the medical toolbox?
    Brian F. Mandell, MD, PhD
    Cleveland Clinic Journal of Medicine April 2025, 92 (4) 200-201; DOI: https://doi.org/10.3949/ccjm.92b.04025

    Given the historical association of psychedelics as “recreational” mind-altering compounds within countercultures of the 1960s and 1970s, their current introduction into several aspects of medical practice is a surprise to many.

  • You have access
    Nociplastic pain: A practical guide to chronic pain management in the primary care setting
    Rupak Thapa, MD and Dennis Ang, MD
    Cleveland Clinic Journal of Medicine April 2025, 92 (4) 236-247; DOI: https://doi.org/10.3949/ccjm.92a.24101

    Nociplastic pain is characterized by amplification of pain transmission and pain perception and does not involve visible tissue injury or damage, which makes it difficult to understand and manage.

  • You have access
    Psychedelics, spirituality, and existential distress in patients at the end of life
    Nicole Cornish, PharmD, Tara Coles, MD, M. Jennifer Cheng, MD, Claudia Ruiz Sotomayor, MD, DBe, Aaron Wolfgang, MD and Christopher Spevak, MD, MPH, JD
    Cleveland Clinic Journal of Medicine April 2025, 92 (4) 248-254; DOI: https://doi.org/10.3949/ccjm.92a.24100

    The authors explore the role of psychedelics in addressing patients’ spiritual and existential suffering at the end of life from a medical, ethical, and legal perspective.

  • You have access
    Reducing the risks when using benzodiazepines to treat insomnia: A public health approach
    Vania Modesto-Lowe, MD, MPH, Margaret M. Chaplin, MD, Roberto León-Barriera, MD and Lakshit Jain, MD
    Cleveland Clinic Journal of Medicine May 2024, 91 (5) 293-299; DOI: https://doi.org/10.3949/ccjm.91a.23061

    The authors review measures for preventing harm before benzodiazepines are prescribed, decreasing harm within 4 weeks after they are prescribed, and limiting harmful effects of long-term prescribing.

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