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Commentary

Another influenza season in the shadow of the COVID-19 pandemic

Sherif Beniameen Mossad, MD, FACP, FIDSA, FAST
Cleveland Clinic Journal of Medicine November 2021, 88 (11) 594-597; DOI: https://doi.org/10.3949/ccjm.88a.21095
Sherif Beniameen Mossad
Department of Infectious Diseases, Respiratory Institute and Transplant Center, Cleveland Clinic, Professor of Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
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Article Figures & Data

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    TABLE 1

    Distinct features of influenza and COVID-19

    InfluenzaCOVID-19
    SeasonalityFall-winterYear-round
    Annual incidence
     Overall8% (3% –11%)6%–8%
     Children20% (unvaccinated)Not applicable (no vaccine)
     Adults10% (unvaccinated)6%–8% (unvaccinated)
    Age distributionChildren > adultsAdults > children
    Incubation period (days)1 –4 days2– 14 days
    Duration of infectivity1 day before to 7 days after onset of illness2 days before to 10 (20 for severe cases) days after onset of illness
    Onset of symptomsMore acuteMore subacute
    Super-spreaders (1 person infects 8 persons)Not reported1%
    Typical or characteristic features at onset of illnessFever, headache, dry coughLoss of sense of taste or smell
    Severity of illness
     Asymptomatic5%–50%30%–40%
     Symptomatic
      Mild98%80%
      Moderate1%–2%15%
      Severe0.2%5%
     Fatal0.04%–0.1%3%–4%
    Duration of acute illness5–7 days2– 6 weeks
    Incidence of long-term symptoms lasting longer than 4 weeksClinically silent viral shedding for weeks to months in immunocompromised individuals60%–70% regardless of viral shedding
    ComplicationsPneumoniaDeep venous thrombosis and pulmonary embolism
    Exacerbation of underlying chronic heart and lung diseasesMultisystem inflammatory disorders
    • Data from references 11 and 12.

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Cleveland Clinic Journal of Medicine: 88 (11)
Cleveland Clinic Journal of Medicine
Vol. 88, Issue 11
1 Nov 2021
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Another influenza season in the shadow of the COVID-19 pandemic
Sherif Beniameen Mossad
Cleveland Clinic Journal of Medicine Nov 2021, 88 (11) 594-597; DOI: 10.3949/ccjm.88a.21095

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Another influenza season in the shadow of the COVID-19 pandemic
Sherif Beniameen Mossad
Cleveland Clinic Journal of Medicine Nov 2021, 88 (11) 594-597; DOI: 10.3949/ccjm.88a.21095
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    • US CENTERS FOR DISEASE CONTROL AND PREVENTION GUIDANCE
    • OTHER INFLUENZA VACCINATION RECOMMENDATIONS
    • COVID-19 AND INFLUENZA COINFECTION
    • VACCINE EFFICACY
    • FUTURE DIRECTION
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