The Clinical Picture

Gastrointestinal varicella-zoster virus infection

Nobukazu Agatsuma, MD, Kaoru Tsujioka, MD, Yoshitaka Nishikawa, MD, PhD, Yasuki Nakatani, MD and Yukitaka Yamashita, MD, PhD
Cleveland Clinic Journal of Medicine November 2021, 88 (11) 592-593; DOI: https://doi.org/10.3949/ccjm.88a.20151

A 70-year-old woman was admitted for epigastric pain and generalized skin eruptions. Three months before admission, she was on chemotherapy for acute lymphocytic leukemia.

She had a history of herpes zoster and was vaccinated against varicella. She was taking 2 nonsteroidal anti-inflammatory drugs (NSAIDs), loxoprofen and celecoxib, for chronic back pain caused by degenerative lumbar spondylosis.

On hospital day 1, she described the epigastric pain as of gradual onset, intermittent, and crampy. She reported no odynophagia . Eruptions appeared on her head on day 6. The NSAIDs were discontinued on suspicion of NSAID-related gastritis, and a proton pump inhibitor was administered. However, the epigastric pain worsened, and the eruptions spread to the trunk.

On day 11, partly hemorrhagic vesicles of various sizes with red haloes were observed on her entire body (Figure 1). With a tentative diagnosis of varicella, intravenous acyclovir 250 mg every 8 hour was initiated. Varicella-zoster virus (VZV) antigen was detected from the vesicular lesions via fluorescent antibody assay. On day 17, esophagogastroduodenoscopy showed small, shallow ulcers and erosions surrounded by red haloes, spread diffusely throughout the stomach and duodenum (Figure 2). No esophageal lesions were observed, and the mucosal biopsy was negative for gastric infiltration of acute lymphocytic leukemia. Immunostaining was negative for cytomegalovirus, and VZV-DNA was detected by polymerase chain reaction. She was diagnosed with gastrointestinal VZV infection. After 8 days of antiviral therapy, her symptoms improved, and she was discharged.

Figure 1
Figure 1

Hemorrhagic vesicles with red haloes of various sizes distributed over the whole body.

Figure 2
Figure 2

Esophagogastroduodenoscopy of the stomach showed small, shallow ulcers (arrows) and erosions (arrowheads) surrounded by red haloes spread diffusely in the stomach and duodenum.

RECOGNIZING RISK FOR GASTROINTESTINAL VZV

Gastrointestinal VZV infection should be considered in immunocompromised patients with a history of VZV infection presenting with abdominal pain. Visceral VZV infection is related to reactivation of the latent virus in the enteric nervous system.1 It occurs in 3% to 15% of immunocompromised patients with herpes zoster, with some developing gastrointestinal manifestations.2 In patients who have undergone bone marrow transplant, the risk factors include a highly immunosuppressed state, active graft-vs-host disease, and possibly a history of nondisseminated herpes zoster.

The mortality rate in patients with gastrointestinal VZV infection has been reported to range from 28.6% to 50% despite antiviral therapy.3,4 Although this patient had not undergone bone marrow transplant, the chemotherapy she had received was a potential predisposing factor.2 Esophagogastroduodenos copy should be considered in patients with these risk factors.

Suspicion of gastrointestinal VZV infection and prompt initiation of antiviral therapy are important when gastric ulcers similar to the skin lesions are present. With NSAID-related ulcers, multiple, irregularly shaped lesions are frequently observed in the gastric antrum.5 In contrast, VZV infection-related lesions present as multiple erosions disseminated in the stomach.6 Furthermore, the esophagus, duodenum (as observed in this patient), and the small and large intestines can be involved.7

It is also important to differentiate gastrointestinal VZV infection from gastrointestinal cytomegalovirus infection observed in immunocompromised patients. There has been no direct comparison of gastrointestinal VZV and cytomegalovirus. In one report, the endoscopic appearance of upper-gastrointestinal cytomegalovirus infection was variable and nonspecific, ranging from normal or minimally inflamed mucosa to deep ulceration.8 Therefore, it may be difficult to distinguish gastrointestinal VZV from cytomegalovirus infection based on endoscopic findings alone. However, in the case of gastrointestinal VZV infection, abdominal symptoms can precede the skin lesions by 1 to 10 days, and this more strongly supports VZV.2,3

In this patient, the epigastric pain that preceded the varicella-like skin eruptions, and the diffuse gastroduodenal erosions that resembled the skin lesions revealed on esophagogastroduodenoscopy led to the diagnosis. Treatment with acyclovir before obtaining the definitive diagnosis (by polymerase chain reaction testing) ameliorated the patient’s symptoms. Thus, clinicians should be vigilant for gastrointestinal VZV infection in patients with gastric ulcers and skin lesions.

DISCLOSURES

The authors report no relevant financial relationships which, in the context of their contributions, could be perceived as a potential conflict of interest.

REFERENCES

  1. ↵
    1. Chen JJ,
    2. Gershon AA,
    3. Li Z,
    4. Cowles RA,
    5. Gershon MD
    . Varicella zoster virus (VZV) infects and establishes latency in enteric neurons. J Neurovirol 2011; 17(6):578–589. doi:10.1007/s13365-011-0070-1
    OpenUrlCrossRefPubMed
  2. ↵
    1. Stratman E
    . Visceral zoster as the presenting feature of disseminated herpes zoster. J Am Acad Dermatol 2002; 46(5):771–774. doi:10.1067/mjd.2002.119091
    OpenUrlCrossRefPubMed
  3. ↵
    1. David DS,
    2. Tegtmeier BR,
    3. O’Donnell MR,
    4. Paz IB,
    5. McCarty TM
    . Visceral varicella-zoster after bone marrow transplantation: report of a case series and review of the literature. Am J Gastroenterol 1998; 93(5):810–813. doi:10.1111/j.1572-0241.1998.230_a.x
    OpenUrlCrossRefPubMed
  4. ↵
    1. Yagi T,
    2. Karasuno T,
    3. Hasegawa T, et al
    . Acute abdomen without cutaneous signs of varicella zoster virus infection as a late complication of allogeneic bone marrow transplantation: importance of empiric therapy with acyclovir. Bone Marrow Transplant 2000; 25(9):1003–1005. doi:10.1038/sj.bmt.1702340
    OpenUrlCrossRefPubMed
  5. ↵
    1. Kim Y,
    2. Yokoyama S,
    3. Watari J, et al
    . Endoscopic and clinical features of gastric ulcers in Japanese patients with or without Helicobacter pylori infection who were using NSAIDs or low-dose aspirin. J Gastroenterol 2012; 47(8):904–911. doi:10.1007/s00535-012-0553-8
    OpenUrlCrossRefPubMed
  6. ↵
    1. Hsu CC,
    2. Hsu CC,
    3. Rosenberg RM
    . Gastrointestinal manifestations of disseminated varicella. Gastroenterol Hepatol (NY) 2014; 10(10):682–683. pmid:27540342
    OpenUrlPubMed
  7. ↵
    1. Serris A,
    2. Michot J-M,
    3. Fourn E, et al
    . Disseminated varicella-zoster virus infection with hemorrhagic gastritis during the course of chronic lymphocytic leukemia: case report and literature review [article in French]. La Rev Med Interne 2014; 35(5):337–340. doi:10.1016/j.revmed.2013.05.004
    OpenUrlCrossRefPubMed
  8. ↵
    1. Marques S,
    2. Carmo J,
    3. Pinto D,
    4. Bispo M,
    5. Ramos S,
    6. Chagas C
    . Cytomegalovirus disease of the upper gastrointestinal tract: A 10-year retrospective study. GE Port J Gastroenterol 2017; 24(6):262–268. doi:10.1159/000479232
    OpenUrlCrossRef
Back to top

In this issue

Print
Download PDF
Article Alerts
Email Article
Citation Tools

Jump to section

Subjects