Table of Contents
From the Editor
- SGLT-2 inhibitors are potential game-changers (for more than diabetes)
Data from large clinical trials and improved understanding of the biologic effects of these drugs are changing expectations for the clinical course in patients with diabetes, as well as chronic kidney disease and heart failure.
The Clinical Picture
- Gastrointestinal varicella-zoster virus infection
Esophagogastroduodenoscopy showed small, shallow ulcers and erosions surrounded by red haloes, spread diffusely throughout the stomach and duodenum.
The Clinical Picture
- Generalized acute cutaneous lupus erythematosus in a young female
A history of systemic lupus and discontinuation of medications for 3 months led to increased disease activity.
Commentary
- SGLT-2 inhibitors in heart failure: Time for broader eligibility and earlier initiation
SGLT-2 inhibitors remain vastly underused in clinical practice despite their broad cardiorenal benefits.
Medical Grand Rounds
- Options for preserving fertility in women undergoing gonadotoxic treatment
For females undergoing cancer therapy, proactive treatments can help preserve the possibility of having children.
Review
- DXA and clinical challenges of fracture risk assessment in primary care
Overdependence on dual-energy x-ray absorptiometry, especially for patient populations the test was not designed for, may lead to poor clinical decisions.
- Spontaneous coronary artery dissection: Principles of management
Once thought to be rare, it is increasingly recognized as a common cause of acute coronary syndrome, particularly in young women.
1-Minute Consult
- Should my older adult patients take aspirin for primary prevention of cardiovascular disease?
For patients age 70 and older, recent evidence shows that the harms outweigh the benefits.
Review
- Elevated hCG can be a benign finding in perimenopausal and postmenopausal women
A search for the source of the elevation in perimenopausal and postmenopausal women who are not pregnant and have no disease or tumor may delay patient care.
Commentary
Flu season is upon us at the ominous milestone of more than 722,000 US deaths from COVID-19.