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Very high fracture risk, unable to come off glucocorticoid therapy High fracture risk, with P1NP level that remains high after 2 years on teriparatide High fracture risk, with multiple vertebral compression fractures at baseline but none while on teriparatide Adynamic renal bone disease Severe chronic obstructive pulmonary disease and vertebral compression fractures P1NP = procollagen type 1 N-terminal propeptide