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Guidelines to Practice

Diagnostic stewardship for urinary tract infection: A snapshot of the expert guidance

Glenn T. Werneburg, MD, PhD and Daniel D. Rhoads, MD
Cleveland Clinic Journal of Medicine October 2022, 89 (10) 581-587; DOI: https://doi.org/10.3949/ccjm.89a.22008
Glenn T. Werneburg
Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH
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  • For correspondence: wernebg@ccf.org
Daniel D. Rhoads
Department of Laboratory Medicine, Cleveland Clinic, Cleveland, OH; Infection Biology Program, Lerner Research Institute, Cleveland Clinic, Cleveland, OH; Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
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    TABLE 1

    Ordering, processing, and reporting urine cultures: Key points of the expert guidance

    StageAppropriate practices
    OrderingRequire documentation of proper (eg, clean-catch) collection
    Only test patients with documented signs and symptoms of urinary tract infection
    ProcessingUse a reflex-culture protocol when possible, so urine without inflammatory markers (ie, white blood cells) is not cultured, as this helps prevent microbial characterization and inappropriate treatment of asymptomatic bacteriuria
    Do not routinely work up any isolates when more than 2 types of bacteria are recovered by culture
    ReportingOptimize laboratory reporting:
    • Include a disclaimer that high colony counts can be present in asymptomatic bacteriuria

    • “Nudge” prescribers not to treat asymptomatic bacteriuria or mixed growth

    • Clearly define identified isolates as uropathogen or probable skin contaminant

    • Use antibiotic cascade reporting, which does not report fluoroquinolones as first-line antibiotics

    • Based on information in reference 1.

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    TABLE 2

    Ordering urine cultures: Appropriate and inappropriate signs and symptoms to document

    Urinary catheter statusAppropriate sign or symptomInappropriate sign
    Patient without a urinary catheterDysuria, suprapubic pain, flank pain, costovertebral angle tenderness, septic shockAltered mental status, change in urine characteristics
    Patient with a urinary catheterDysuria, suprapubic pain, flank pain, costovertebral angle tenderness, or septic shockChange in urine characteristics
    • Based on information in reference 1.

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Cleveland Clinic Journal of Medicine: 89 (10)
Cleveland Clinic Journal of Medicine
Vol. 89, Issue 10
1 Oct 2022
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Diagnostic stewardship for urinary tract infection: A snapshot of the expert guidance
Glenn T. Werneburg, Daniel D. Rhoads
Cleveland Clinic Journal of Medicine Oct 2022, 89 (10) 581-587; DOI: 10.3949/ccjm.89a.22008

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Diagnostic stewardship for urinary tract infection: A snapshot of the expert guidance
Glenn T. Werneburg, Daniel D. Rhoads
Cleveland Clinic Journal of Medicine Oct 2022, 89 (10) 581-587; DOI: 10.3949/ccjm.89a.22008
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  • Article
    • ABSTRACT
    • CLINICAL SETTING
    • INTENDED AUDIENCE
    • WHO WROTE THE GUIDELINES?
    • WHAT ARE THE MAIN RECOMMENDATIONS?
    • WHAT IS DIFFERENT FROM PREVIOUS GUIDELINES?
    • WHAT IS THE EXPECTED CLINICAL IMPACT?
    • DO OTHER SOCIETIES AGREE OR DISAGREE?
    • HOW WILL THIS CHANGE DAILY PRACTICE?
    • SPECIAL CONSIDERATIONS: WHEN WOULD THE GUIDANCE NOT APPLY?
    • DISCLOSURES
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