Review

Late complications after allogeneic hematopoietic cell transplant: What primary care physicians can do

Lauren M. Granat, DO, MS, Mariah Ondeck, MD, Bennett Osantowski, MD, Michael Sheu, MD, Vishwanath Ganesan, MD, Seth Rotz, MD and Betty K. Hamilton, MD
Cleveland Clinic Journal of Medicine August 2023, 90 (8) 499-508; DOI: https://doi.org/10.3949/ccjm.90a.23006

ABSTRACT

Survivors of allogeneic hematopoietic cell transplant (HCT) face the risk of many serious complications in the long term, which primary care physicians play an integral role in recognizing and treating. In this review, the authors summarize the most common complications that primary care physicians see after HCT recipients return to their care: chronic graft-vs-host disease; cardiovascular, metabolic, endocrine, rheumatologic, orthopedic, infectious, neurologic, and cognitive complications; secondary malignancies; psychiatric disorders; and impairments in quality of life and sexual health. Also discussed are health maintenance and screening recommendations for this patient population.

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  1. Lauren M. Granat, DO, MS⇑
  1. Chief Resident, Department of Internal Medicine, Cleveland Clinic, Cleveland, OH
  1. Address:
    Lauren M. Granat, DO, MS, Department of Internal Medicine, NA10, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195; granatl2{at}ccf.org
  1. Mariah Ondeck, MD
  1. PGY3, Department of Internal Medicine, Cleveland Clinic, Cleveland, OH
  1. Bennett Osantowski, MD
  1. PGY3, Department of Internal Medicine, Cleveland Clinic, Cleveland, OH
  1. Michael Sheu, MD
  1. PGY3, Department of Internal Medicine, Cleveland Clinic, Cleveland, OH
  1. Vishwanath Ganesan, MD
  1. PGY3, Department of Internal Medicine, Cleveland Clinic, Cleveland, OH
  1. 21990-seth-rotzSeth Rotz, MD
  1. Staff Physician, Department of Pediatric Hematology, Oncology, and Blood and Marrow Transplant, Cleveland Clinic, Cleveland, OH; Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
  1. 18208-betty-hamiltonBetty K. Hamilton, MD
  1. Staff Physician, Blood and Marrow Transplant Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH; Associate Professor of Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH

ABSTRACT

Survivors of allogeneic hematopoietic cell transplant (HCT) face the risk of many serious complications in the long term, which primary care physicians play an integral role in recognizing and treating. In this review, the authors summarize the most common complications that primary care physicians see after HCT recipients return to their care: chronic graft-vs-host disease; cardiovascular, metabolic, endocrine, rheumatologic, orthopedic, infectious, neurologic, and cognitive complications; secondary malignancies; psychiatric disorders; and impairments in quality of life and sexual health. Also discussed are health maintenance and screening recommendations for this patient population.

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