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Review

Nociplastic pain: A practical guide to chronic pain management in the primary care setting

Rupak Thapa, MD and Dennis Ang, MD
Cleveland Clinic Journal of Medicine April 2025, 92 (4) 236-247; DOI: https://doi.org/10.3949/ccjm.92a.24101
Rupak Thapa
Department of Rheumatology, Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, NC; Assistant Professor, Wake Forest University School of Medicine, Winston-Salem, NC
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  • For correspondence: [email protected]
Dennis Ang
Chair, Department of Rheumatology, Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, NC; Professor, Wake Forest University School of Medicine, Winston-Salem, NC
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Article Information

vol. 92 no. 4 236-247
DOI 
https://doi.org/10.3949/ccjm.92a.24101
PubMed 
40169217

Published By 
Cleveland Clinic Journal of Medicine
Print ISSN 
0891-1150
Online ISSN 
1939-2869
History 
  • Published online April 1, 2025.

Copyright & Usage 
Copyright © 2025 The Cleveland Clinic Foundation. All Rights Reserved.

Author Information

  1. Rupak Thapa, MD⇑
  1. Department of Rheumatology, Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, NC; Assistant Professor, Wake Forest University School of Medicine, Winston-Salem, NC
  1. Address:
    Rupak Thapa, MD, Department of Rheumatology, Atrium Health Wake Forest Baptist Medical Center, 1 Medical Center Boulevard, Winston Salem, NC 27157; rthapa{at}wakehealth.edu
  1. Dennis Ang, MD
  1. Chair, Department of Rheumatology, Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, NC; Professor, Wake Forest University School of Medicine, Winston-Salem, NC
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Cleveland Clinic Journal of Medicine: 92 (4)
Cleveland Clinic Journal of Medicine
Vol. 92, Issue 4
1 Apr 2025
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Nociplastic pain: A practical guide to chronic pain management in the primary care setting
Rupak Thapa, Dennis Ang
Cleveland Clinic Journal of Medicine Apr 2025, 92 (4) 236-247; DOI: 10.3949/ccjm.92a.24101

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Nociplastic pain: A practical guide to chronic pain management in the primary care setting
Rupak Thapa, Dennis Ang
Cleveland Clinic Journal of Medicine Apr 2025, 92 (4) 236-247; DOI: 10.3949/ccjm.92a.24101
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  • Article
    • ABSTRACT
    • PAIN CATEGORIZATION
    • MECHANISMS OF NOCIPLASTIC PAIN
    • CHALLENGES AND MITIGATION STRATEGIES
    • HOW TO IDENTIFY NOCIPLASTIC PAIN
    • UTILITY OF AUTOIMMUNE LABORATORY TESTS FOR CHRONIC PAIN
    • NOCIPLASTIC PAIN MANAGEMENT
    • COORDINATED CARE
    • FINAL THOUGHTS
    • RESOURCES
    • DISCLOSURES
    • Acknowledgments
    • Footnotes
    • REFERENCES
  • Figures & Data
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