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Review

Psychedelics, spirituality, and existential distress in patients at the end of life

Nicole Cornish, PharmD, Tara Coles, MD, M. Jennifer Cheng, MD, Claudia Ruiz Sotomayor, MD, DBe, Aaron Wolfgang, MD and Christopher Spevak, MD, MPH, JD
Cleveland Clinic Journal of Medicine April 2025, 92 (4) 248-254; DOI: https://doi.org/10.3949/ccjm.92a.24100
Nicole Cornish
Georgetown University School of Medicine, Washington, DC
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  • For correspondence: [email protected]
Tara Coles
MedStar Health, Washington, DC; Georgetown University School of Medicine, Washington, DC
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M. Jennifer Cheng
National Institutes of Health Clinical Center, Bethesda, MD
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Claudia Ruiz Sotomayor
Georgetown University Medical Center, Washington, DC
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Aaron Wolfgang
Walter Reed National Military Medical Center, Bethesda, MD; Uniformed Services University, Bethesda, MD; Yale School of Medicine, New Haven, CT
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Christopher Spevak
Georgetown University School of Medicine, Washington, DC
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Article Information

vol. 92 no. 4 248-254
DOI 
https://doi.org/10.3949/ccjm.92a.24100
PubMed 
40169224

Published By 
Cleveland Clinic Journal of Medicine
Print ISSN 
0891-1150
Online ISSN 
1939-2869
History 
  • Published online April 1, 2025.

Copyright & Usage 
Copyright © 2025 The Cleveland Clinic Foundation. All Rights Reserved.

Author Information

  1. Nicole Cornish, PharmD⇑
  1. Georgetown University School of Medicine, Washington, DC
  1. Address:
    Nicole Cornish, PharmD, Georgetown University School of Medicine, 37th and O Streets NW, Washington, DC 20057; ncornish32{at}gmail.com
  1. Tara Coles, MD
  1. MedStar Health, Washington, DC; Georgetown University School of Medicine, Washington, DC
  1. M. Jennifer Cheng, MD
  1. National Institutes of Health Clinical Center, Bethesda, MD
  1. Claudia Ruiz Sotomayor, MD, DBe
  1. Georgetown University Medical Center, Washington, DC
  1. Aaron Wolfgang, MD
  1. Walter Reed National Military Medical Center, Bethesda, MD; Uniformed Services University, Bethesda, MD; Yale School of Medicine, New Haven, CT
  1. Christopher Spevak, MD, MPH, JD
  1. Georgetown University School of Medicine, Washington, DC

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Cleveland Clinic Journal of Medicine: 92 (4)
Cleveland Clinic Journal of Medicine
Vol. 92, Issue 4
1 Apr 2025
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Psychedelics, spirituality, and existential distress in patients at the end of life
Nicole Cornish, Tara Coles, M. Jennifer Cheng, Claudia Ruiz Sotomayor, Aaron Wolfgang, Christopher Spevak
Cleveland Clinic Journal of Medicine Apr 2025, 92 (4) 248-254; DOI: 10.3949/ccjm.92a.24100

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Psychedelics, spirituality, and existential distress in patients at the end of life
Nicole Cornish, Tara Coles, M. Jennifer Cheng, Claudia Ruiz Sotomayor, Aaron Wolfgang, Christopher Spevak
Cleveland Clinic Journal of Medicine Apr 2025, 92 (4) 248-254; DOI: 10.3949/ccjm.92a.24100
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  • Article
    • ABSTRACT
    • NONPRESCRIPTION USE OF PSYCHEDELICS IS GROWING
    • UTILITY OF PSYCHEDELICS FOR TREATING MENTAL HEALTH DISORDERS
    • EXISTENTIAL DISTRESS AT END OF LIFE
    • MITIGATING EXISTENTIAL DISTRESS WITH TOOLS THAT INCLUDE PSYCHEDELIC-ASSISTED THERAPY
    • LEGAL ISSUES, ETHICAL QUESTIONS AROUND USE OF PSYCHEDELICS
    • THE FUTURE OF PSYCHEDELICS
    • DISCLOSURES
    • Footnotes
    • REFERENCES
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