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Review

Alpha-gal syndrome: Recognizing and managing a tick-bite–related meat allergy

Zehra Naseem, MD, Aun Muhammad, MD, Arjun Chatterjee, MD and Alberto Rubio-Tapia, MD
Cleveland Clinic Journal of Medicine May 2025, 92 (5) 311-319; DOI: https://doi.org/10.3949/ccjm.92a.24072
Zehra Naseem
Department of Internal Medicine, Cleveland Clinic, Cleveland, OH
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Aun Muhammad
Department of Internal Medicine, University of Mississippi Medical Center, Jackson, MS
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Arjun Chatterjee
Department of Gastroenterology, Hepatology & Nutrition, Cleveland Clinic, Cleveland, OH
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Alberto Rubio-Tapia
Department of Gastroenterology, Hepatology & Nutrition, Cleveland Clinic, Cleveland, OH
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Article Information

vol. 92 no. 5 311-319
DOI 
https://doi.org/10.3949/ccjm.92a.24072
PubMed 
40312115

Published By 
Cleveland Clinic Journal of Medicine
Print ISSN 
0891-1150
Online ISSN 
1939-2869
History 
  • Published online May 1, 2025.

Copyright & Usage 
Copyright © 2025 The Cleveland Clinic Foundation. All Rights Reserved.

Author Information

  1. Zehra Naseem, MD
  1. Department of Internal Medicine, Cleveland Clinic, Cleveland, OH
  1. Aun Muhammad, MD
  1. Department of Internal Medicine, University of Mississippi Medical Center, Jackson, MS
  1. Arjun Chatterjee, MD
  1. Department of Gastroenterology, Hepatology & Nutrition, Cleveland Clinic, Cleveland, OH
  1. Alberto Rubio-Tapia, MD⇑
  1. Department of Gastroenterology, Hepatology & Nutrition, Cleveland Clinic, Cleveland, OH
  1. Address:
    Alberto Rubio-Tapia, MD, Department of Gastroenterology, Hepatology & Nutrition, A31, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195; rubiota{at}ccf.org
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Cleveland Clinic Journal of Medicine: 92 (5)
Cleveland Clinic Journal of Medicine
Vol. 92, Issue 5
1 May 2025
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Alpha-gal syndrome: Recognizing and managing a tick-bite–related meat allergy
Zehra Naseem, Aun Muhammad, Arjun Chatterjee, Alberto Rubio-Tapia
Cleveland Clinic Journal of Medicine May 2025, 92 (5) 311-319; DOI: 10.3949/ccjm.92a.24072

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Alpha-gal syndrome: Recognizing and managing a tick-bite–related meat allergy
Zehra Naseem, Aun Muhammad, Arjun Chatterjee, Alberto Rubio-Tapia
Cleveland Clinic Journal of Medicine May 2025, 92 (5) 311-319; DOI: 10.3949/ccjm.92a.24072
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  • Article
    • ABSTRACT
    • WHAT IS ALPHA-GAL SYNDROME?
    • HOW TICK BITES CAN INDUCE A MEAT ALLERGY
    • RANGE OF SYMPTOMS AND TRIGGERS
    • MEDICAL PRODUCTS THAT CONTAIN ALPHA-GAL CAN TRIGGER ALLERGIC REACTIONS
    • WHEN TO CONSIDER ALPHA-GAL SYNDROME
    • DIAGNOSIS IS A CHALLENGE
    • MANAGEMENT OF ALPHA-GAL SYNDROME
    • PREVENTING TICK BITES
    • ADVICE FOR PATIENTS WITH ALPHA-GAL SYNDROME
    • RESEARCH GAPS AND FUTURE IMPLICATIONS
    • TAKE-HOME POINTS
    • DISCLOSURES
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

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