Allergy/Immunology

  • Oral hyperpigmentation with weakness and salt-craving
    Joseph Zhou, MD and S. Sethu K. Reddy, MD, MBA, FRCPC, FACP, MACE
    Cleveland Clinic Journal of Medicine April 2022, 89 (4) 180-181; DOI: https://doi.org/10.3949/ccjm.89a.21036

    The patient’s primary care physician had attributed the hyperpigmentation on the lower lip and inner cheek to pen ink.

  • Does my patient need an allergy evaluation for penicillin allergy?
    Jennifer A. Ohtola, MD, PhD and Sandra J. Hong, MD
    Cleveland Clinic Journal of Medicine March 2022, 89 (3) 126-129; DOI: https://doi.org/10.3949/ccjm.89a.21004

    In patients with reported penicillin allergy, obtaining a detailed allergy history directly from the patient is the essential first step.

  • Anaphylaxis: Highlights from the practice parameter update
    Katherine N. Weller, MD and Fred H. Hsieh, MD
    Cleveland Clinic Journal of Medicine February 2022, 89 (2) 106-111; DOI: https://doi.org/10.3949/ccjm.89a.21076

    The update addresses diagnostic criteria, treatment options, prevention of recurrences, and patient education on avoiding triggers and using self-injectable epinephrine.

  • Anaphylaxis: Expanding our perspective
    Brian F. Mandell, MD, PhD
    Cleveland Clinic Journal of Medicine February 2022, 89 (2) 65; DOI: https://doi.org/10.3949/ccjm.89b.02022

    Anaphylaxis is not always the extreme scenario we learned about in medical school. There is a range of far milder allergic infusion reactions that are nonetheless anaphylaxis.

  • A perspective on discussing COVID-19 vaccines: Efficacy and adverse effects
    Brian F. Mandell, MD
    Cleveland Clinic Journal of Medicine December 2021, 88 (12) 644-645; DOI: https://doi.org/10.3949/ccjm.88b.12021

    Physicians should be vigilant and open-minded regarding possible adverse reactions to the vaccines, and should take time to discuss the demonstrated efficacy of vaccines with patients.

  • COVID-19 vaccine-induced cellulitis and myositis
    Sathishkumar Ramalingam, MD, Harkesh Arora, MD, Susan Lewis, MD, Kulothungan Gunasekaran, MD, Maheswari Muruganandam, MD, Sivakumar Nagaraju, MD and Priyesh Padmanabhan, MD
    Cleveland Clinic Journal of Medicine December 2021, 88 (12) 648-650; DOI: https://doi.org/10.3949/ccjm.88a.21038

    The day after receiving the second dose of the mRNA vaccine, redness and pain developed at the injection site, eventually involving the whole left arm and shoulder.

  • Updated guidelines for immune thrombocytopenic purpura: Expanded management options
    Sherwin DeSouza, MD and Dana Angelini, MD
    Cleveland Clinic Journal of Medicine December 2021, 88 (12) 664-668; DOI: https://doi.org/10.3949/ccjm.88a.20201

    The aim is to help practitioners decide on inpatient vs outpatient management, thresholds for initiating treatment, and options for second-line treatment in adults.

  • Antibody-mediated autoimmune encephalitis: A practical approach
    CME article
    Justin R. Abbatemarco, MD, Chen Yan, MD, Amy Kunchok, MBBS and Alexander Rae-Grant, MD, FAAN, FRCPC
    Cleveland Clinic Journal of Medicine August 2021, 88 (8) 459-471; DOI: https://doi.org/10.3949/ccjm.88a.20122

    Symptoms may include subacute, progressive neuropsychiatric symptoms with associated cognitive dysfunction, movement disorders, and autoimmune seizures.

  • Heightening awareness of blistering disorders
    Brian F. Mandell, MD, PhD
    Cleveland Clinic Journal of Medicine June 2021, 88 (6) 308-309; DOI: https://doi.org/10.3949/ccjm.88b.06021

    The spectrum of associated disorders ranges from annoying to life-threatening.

  • New bullous lesions in a 72-year-old woman
    Hadrian Mendoza, MD, Justin Goodwin, MS, Jeffrey Gehlhausen, MD, Ian Odell, MD, PhD, Jennifer McNiff, MD and Karthik Gnanapandithan, MD
    Cleveland Clinic Journal of Medicine June 2021, 88 (6) 319-324; DOI: https://doi.org/10.3949/ccjm.88a.20180

    Her history included psoriasis, chronic lower-extremity edema, and hypertension.

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