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Review

Alpha-gal syndrome: Recognizing and managing a tick-bite–related meat allergy

Zehra Naseem, MD, Aun Muhammad, MD, Arjun Chatterjee, MD and Alberto Rubio-Tapia, MD
Cleveland Clinic Journal of Medicine May 2025, 92 (5) 311-319; DOI: https://doi.org/10.3949/ccjm.92a.24072
Zehra Naseem
Department of Internal Medicine, Cleveland Clinic, Cleveland, OH
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Aun Muhammad
Department of Internal Medicine, University of Mississippi Medical Center, Jackson, MS
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Arjun Chatterjee
Department of Gastroenterology, Hepatology & Nutrition, Cleveland Clinic, Cleveland, OH
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Alberto Rubio-Tapia
Department of Gastroenterology, Hepatology & Nutrition, Cleveland Clinic, Cleveland, OH
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    Figure 1

    The lone star tick (Amblyomma americanum).

    Reprinted from US Centers for Disease Control and Prevention. Lone Star Tick Surveillance. www.cdc.gov/ticks/data-research/facts-stats/lone-star-tick-surveillance.html.

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    Figure 2

    US Centers for Disease Control and Prevention data on the geographic distribution of suspected cases of allergy to galactose-alpha-1,3-galac-tose (alpha-gal syndrome) per 1 million population per year in the United States (2017–2022).

    Reprinted from reference 4.

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    Figure 3

    Distribution map of the lone star tick (Amblyomma americanum) in the United States.

    Reprinted from US Centers for Disease Control and Prevention. Lone Star Tick (Amblyomma americanum). stacks.cdc.gov/view/cdc/25414.

  • Figure 4
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    Figure 4

    Algorithm for the diagnosis and management of presumed allergy to galactose-alpha-1,3-galactose (alpha-gal syndrome).

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    TABLE 1

    Food and product safety for patients with alpha-gal syndrome

    Contain alpha-gal
    Foods
     Meat: beef, pork, lamb, venison, rabbit, goat, buffalo, bison horse
     Animal viscera: kidney, liver, heart, intestine, lung
     Gelatin from beef and pork: marshmallow, gummy bears, other gelatin-based items
     Lard and tallow
     Cow’s milk and cow’s milk–based items: butter, cheese, yogurt, cream, cream cheese, ice cream
     Nut milks
    Medical products
     Gelatin-containing vaccines: measles, mumps, and rubella; yellow fever; live attenuated zoster
     Glycerol
     Magnesium stearate
     Porcine-sourced heparin
     Monoclonal antibodies
     Thrombin
     Bovine-derived pancreatic enzymes
     Porcine and bovine heart valves
     Equine-derived antivenin
    Personal care products
     Lanolin
     Collagen
     Glycerin
    Do not contain alpha-gal
    Meat: chicken, turkey, duck
    Seafood
    Fish
    Eggs
    Fruits
    Vegetables
    • Alpha-gal = galactose-alpha-1,3-galactose.

    • Based on information from references 15 and 24.

    • View popup
    TABLE 2

    Recommended medications

    IndicationMedication and dose
    Frequent travelFexofenadine 180 mg daily32
    Levocetirizine 5 mg daily in the evening32
    Montelukast 10 mg daily in the evening33
    Predominant gastrointestinal symptomsOral cromolyn solution 100 to 200 mg, 2 to 4 times daily, 20 to 30 minutes before meals15
    Refractory symptomsOmalizumab (dose based on weight and immunoglobulin E levels)31
    Severe symptomsaSelf-injectable epinephrine3
    • ↵a Respiratory compromise, hypotension, severe angioedema.

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Cleveland Clinic Journal of Medicine: 92 (5)
Cleveland Clinic Journal of Medicine
Vol. 92, Issue 5
1 May 2025
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Alpha-gal syndrome: Recognizing and managing a tick-bite–related meat allergy
Zehra Naseem, Aun Muhammad, Arjun Chatterjee, Alberto Rubio-Tapia
Cleveland Clinic Journal of Medicine May 2025, 92 (5) 311-319; DOI: 10.3949/ccjm.92a.24072

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Alpha-gal syndrome: Recognizing and managing a tick-bite–related meat allergy
Zehra Naseem, Aun Muhammad, Arjun Chatterjee, Alberto Rubio-Tapia
Cleveland Clinic Journal of Medicine May 2025, 92 (5) 311-319; DOI: 10.3949/ccjm.92a.24072
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Jump to section

  • Article
    • ABSTRACT
    • WHAT IS ALPHA-GAL SYNDROME?
    • HOW TICK BITES CAN INDUCE A MEAT ALLERGY
    • RANGE OF SYMPTOMS AND TRIGGERS
    • MEDICAL PRODUCTS THAT CONTAIN ALPHA-GAL CAN TRIGGER ALLERGIC REACTIONS
    • WHEN TO CONSIDER ALPHA-GAL SYNDROME
    • DIAGNOSIS IS A CHALLENGE
    • MANAGEMENT OF ALPHA-GAL SYNDROME
    • PREVENTING TICK BITES
    • ADVICE FOR PATIENTS WITH ALPHA-GAL SYNDROME
    • RESEARCH GAPS AND FUTURE IMPLICATIONS
    • TAKE-HOME POINTS
    • DISCLOSURES
    • REFERENCES
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