Article Figures & Data
Figures
- FIGURE 1
Enhanced reproducibility of hemoglobin A1c over time.7 Shown as mean (± 2 standard deviations) of methods compared with NGSP/DCCT target in 1993, 1999, 2004, and 2012. DCCT = Diabetes Control and Complications Trial; NGSP = National Glycohemoglobin Standardization Program
Reprinted from Clinica Chimica Acta (Little RR, Rohlfing CL. The long and winding road to optimal HbA1c measurement. Clin Chim Acta 2013; 418:63–71). © 2013 with permission from Elsevier. http://www.sciencedirect.com/science/journal/00098981.
- FIGURE 2
Schematic for setting hemoglobin A1c (HbA1c) goals according to a patient-tailored approach.
Reprinted with permission from: Inzucchi SI, Bergenstal RM, Buse JB, et al. Management of hyperglycemia in type 2 diabetes: 2015: A patient-centered approach. Update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2015; 38:140–149.
Tables
HbA1c (%) Mean plasma glucose (mg/dL) IFCC units (mmol/mol) 6 126 42 6.5 141 48 7 154 53 7.5 169 59 8 183 64 8.5 198 69 9 212 75 9.5 226 80 10 240 86 11 269 97 12 298 108 IFCC = International Federation of Clinical Chemistry and Laboratory Medicine.
Measurement ADA 2015 diagnostic values Hemoglobin A1c ≥ 6.5% (48 mmol/mol) Fasting plasma glucose ≥ 126 mg/dL (7.0 mmol/L) 2-Hour postprandial plasma glucose ≥ 200 mg/dL (11.1 mmol/L) ADA = American Diabetes Association.
Based on information in American Diabetes Association. Classification and diagnosis of diabetes. Sec. 2. In: Standards of Medical Care in Diabetes—2015. Diabetes Care 2015; 38(suppl 1):S8–S16.
Age ≥ 45 BMI ≥ 25 kg/m2 or ≥ 23 kg/m2 in Asian populations First-degree relative with diabetes High-risk race/ethnicity (African American, Latino, Native American, Asian, Pacific Islander) Women with history of gestational diabetes mellitus or who delivered a baby weighing > 9 lb (4 kg) Hypertension (≥ 140/90 mm Hg or on therapy for hypertension) Dyslipidemia: HDL cholesterol < 35 mg/dL (0.90 mmol/L), triglyceride > 250 mg/dL (2.82 mmol/L), or both Women with polycystic ovary syndrome Prior history of HbA1c ≥ 5.7%, IGT, or IFG Acanthosis nigricans, severe obesity, or other conditions associated with insulin resistance History of cardiovascular disease Physical inactivity BMI = body mass index; HbA1c = hemoglobin A1c; HDL = high-density lipoprotein; IFG = impaired fasting glucose; IGT = impaired glucose tolerance.
Based on information in American Diabetes Association. Classification and diagnosis of diabetes. Sec. 2. In: Standards of Medical Care in Diabetes—2015. Diabetes Care 2015; 38(suppl 1):S8–S16.
Measurement ADA 2015 criteria16 WHO 2006/2011 criteria13,15 Hemoglobin A1c 5.7%–6.4%
(39–46 mmol/mol)6.0%–6.5%
(42–48 mmol/mol)Fasting plasma glucose 100–125 mg/dL
(5.6–6.9 mmol/L)110–125 mg/dL
(6.1–6.9 mmol/L)2-Hour postprandial plasma glucose 140–199 mg/dL
(7.8–11.0 mmol/L)140–200 mg/dL
(7.8–11.1 mmol/L)ADA = American Diabetes Association; WHO = World Health Organization.
