Medical Grand Rounds

Thrombotic microangiopathies: Similar presentations, different therapies

Gerald B. Appel, MD
Cleveland Clinic Journal of Medicine February 2017, 84 (2) 114-130; DOI: https://doi.org/10.3949/ccjm.84gr.17001

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Tables

  • TABLE 1

    Conditions associated with thrombotic microangiopathy

    Thrombotic thrombocytopenic purpura
    Shiga toxin hemolytic uremic syndrome
    Atypical hemolytic uremic syndrome (due to activation of the alternate complement pathway)
    Antiphospholipid antibody syndrome, often associated with systemic lupus erythematosus
    Progressive systemic sclerosis
    Infections, eg, human immunodeficiency virus
    Pregnancy, preeclampsia, eg, hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome
    Drug-induced, eg, mitomycin, gemcitabine, vascular endothelial growth factor inhibitors, quinine, calcineurin inhibitors
    Stem cell transplant
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