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Symptoms to Diagnosis

Shortness of breath, fever, cough, and more in an elderly woman

Brody D. Slostad, MD, Megha Prasad, MD and Nandan S. Anavekar, MD
Cleveland Clinic Journal of Medicine September 2018, 85 (9) 685-692; DOI: https://doi.org/10.3949/ccjm.85a.18030
Gregory W. Rutecki
Department of Internal Medicine, Mayo Clinic, Rochester, MN
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Brody D. Slostad
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  • For correspondence: [email protected]
Megha Prasad
Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN
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Nandan S. Anavekar
Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN
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    Figure 1

    Chest computed tomography axial views demonstrated increased attenuation in the liver (A, arrow) and left pleural base (B, arrow). Evaluation of the right lung base revealed ground-glass opacities (C, arrow) and honeycombing (D, arrow). These findings were consistent with amiodarone pulmonary toxicity.

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    Figure 2

    In A, repeat chest computed tomography demonstrated increased liver attenuation (arrow); in B, it showed persistent ground-glass opacities (white arrow), increased pulmonary attenuation (black arrowhead), and worsening pleural effusions (black arrows). These findings supported the diagnosis of amiodarone pulmonary toxicity.

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    TABLE 1

    The patient’s laboratory values

    TestValueaReference range
    Hemoglobin8.512.0–15.5 g/dL
    Mean corpuscular volume125.781.6–98.3 fL
    Peripheral smearOval macrocytes and hypersegmented neutrophils
    Vitamin B12462180–914 ng/L
    Folate6.7> 4 µg/L
    White blood cell count8.93.5–10.5 × 109/L
    Neutrophils95%42%–75%
    Lymphocytes2%16%–52%
    Monocytes5%1%–11%
    Platelet count105150–450 × 109/L
    Creatinine1.20.6–1.1 mg/dL
    Sodium138135–145 mmol/L
    Potassium3.63.6–5.2 mmol/L
    Troponin T0.02< 0.01 ng/mL
     At 3 and 6 hours later0.01
    N-terminal pro-B-type natriuretic peptide22,0005–263 pg/mL
    Thyroid-stimulating hormone0.80.3–5.0 mIU/L
    Free thyroxine1.910.7–1.9 ng/dL
    Aspartate aminotransferase1078–43 U/L
    Alanine aminotransferase1177–45 U/L
    • ↵a Abnormal results are shown in bold.

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Cleveland Clinic Journal of Medicine: 85 (9)
Cleveland Clinic Journal of Medicine
Vol. 85, Issue 9
1 Sep 2018
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Shortness of breath, fever, cough, and more in an elderly woman
Brody D. Slostad, Megha Prasad, Nandan S. Anavekar
Cleveland Clinic Journal of Medicine Sep 2018, 85 (9) 685-692; DOI: 10.3949/ccjm.85a.18030

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Shortness of breath, fever, cough, and more in an elderly woman
Brody D. Slostad, Megha Prasad, Nandan S. Anavekar
Cleveland Clinic Journal of Medicine Sep 2018, 85 (9) 685-692; DOI: 10.3949/ccjm.85a.18030
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  • Article
    • WHAT IS THE CAUSE OF HER SYMPTOMS?
    • OUR PATIENT UNDERWENT FURTHER TESTING
    • WHAT IS THE CAUSE OF HER PERSISTENT PULMONARY FINDINGS?
    • WHAT IS THE NEXT STEP?
    • FOLLOW-UP 1 MONTH LATER
    • WHAT FURTHER TREATMENT IS APPROPRIATE?
    • CASE CONCLUSION
    • MORE ABOUT AMIODARONE PULMONARY TOXICITY
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