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Cleveland Clinic Journal of Medicine

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Review

Sepsis and septic shock: Guideline-based management

Siddharth Dugar, MD, Chirag Choudhary, MD, MBA and Abhijit Duggal, MD, MPH, MSc, FACP
Cleveland Clinic Journal of Medicine January 2020, 87 (1) 53-64; DOI: https://doi.org/10.3949/ccjm.87a.18143
Siddharth Dugar
Department of Critical Care, Respiratory Institute, Cleveland Clinic; Clinical Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
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Chirag Choudhary
Department of Critical Care, Respiratory Institute, Cleveland Clinic; Clinical Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
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Abhijit Duggal
Department of Critical Care, Respiratory Institute, Cleveland Clinic; Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
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ABSTRACT

Sepsis is a life-threatening organ dysfunction that results from the body’s response to infection. It requires prompt recognition, appropriate antibiotics, careful hemodynamic support, and control of the source of infection. With the trend in management moving away from protocolized care in favor of appropriate usual care, an understanding of sepsis physiology and best practice guidelines is critical.

  • Copyright © 2020 The Cleveland Clinic Foundation. All Rights Reserved.
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  1. Siddharth Dugar, MD
  1. Department of Critical Care, Respiratory Institute, Cleveland Clinic; Clinical Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
  1. Chirag Choudhary, MD, MBA
  1. Department of Critical Care, Respiratory Institute, Cleveland Clinic; Clinical Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
  1. Abhijit Duggal, MD, MPH, MSc, FACP⇑
  1. Department of Critical Care, Respiratory Institute, Cleveland Clinic; Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
  1. Address:
    Abhijit Duggal, MD, MPH, MSc, FACP, Department of Critical Care Medicine, Respiratory Institute, G62, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio. 44195; duggala2{at}ccf.org

ABSTRACT

Sepsis is a life-threatening organ dysfunction that results from the body’s response to infection. It requires prompt recognition, appropriate antibiotics, careful hemodynamic support, and control of the source of infection. With the trend in management moving away from protocolized care in favor of appropriate usual care, an understanding of sepsis physiology and best practice guidelines is critical.

  • Copyright © 2020 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 87 (1)
Cleveland Clinic Journal of Medicine
Vol. 87, Issue 1
1 Jan 2020
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Sepsis and septic shock: Guideline-based management
Siddharth Dugar, Chirag Choudhary, Abhijit Duggal
Cleveland Clinic Journal of Medicine Jan 2020, 87 (1) 53-64; DOI: 10.3949/ccjm.87a.18143

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Sepsis and septic shock: Guideline-based management
Siddharth Dugar, Chirag Choudhary, Abhijit Duggal
Cleveland Clinic Journal of Medicine Jan 2020, 87 (1) 53-64; DOI: 10.3949/ccjm.87a.18143
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  • Article
    • ABSTRACT
    • COMMON AND LIFE-THREATENING
    • DEFINITIONS HAVE EVOLVED
    • TOOLS FOR IDENTIFYING HIGH RISK: SOFA AND qSOFA
    • ANTIMICROBIAL THERAPY
    • FLUID RESUSCITATION
    • EARLY SOURCE CONTROL
    • RESTORING BLOOD PRESSURE
    • ROLE OF CORTICOSTEROIDS IS QUESTIONED
    • BIOMARKERS
    • USUAL CARE VS PROTOCOLIZED INITIAL RESUSCITATION
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  • Whole-Genome Sequencing, Annotation and Taxonomic Confirmation of a Multidrug-Resistant Escherichia coli Isolated from the Blood of a Sepsis Patient
  • The Circulating CDC42 Expression in Sepsis: Relation to Disease Susceptibility, Inflammation, Multiple Organ Dysfunctions and Mortality Risk
  • Model-guided Design of Biological Controller for Septic Wound Healing Regulation
  • Risk factors for mortality of adult patients with COVID-19 hospitalised in an emerging country: a cohort study
  • Class-Modeling of Septic Shock With Hyperdimensional Computing
  • Evaluation and management of shock in patients with COVID-19
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