Table of Contents

January 01, 2020; Volume 87,Issue 1

From the Editor

  • Modifying genetic diseases: Promises to be realized?
    Brian F. Mandell, MD, PhD
    Cleveland Clinic Journal of Medicine January 2020, 87 (1) 7-8; DOI: https://doi.org/10.3949/ccjm.87b.01020

    Genetic engineering offers hope to patients and families who previously had little.

The Clinical Picture

  • Giant uric acid stone in the bladder
    Alexander E. Sullivan, MD and Suchita Shah Sata, MD
    Cleveland Clinic Journal of Medicine January 2020, 87 (1) 14-15; DOI: https://doi.org/10.3949/ccjm.87a.19069

    The patient said he had to urinate 30 to 40 times a day, but only in small amounts.

Commentary

Editorial

  • Gene therapy in sickle cell disease: Possible utility and impact
    Susanna A. Curtis, MD, MS and Niketa C. Shah, MD
    Cleveland Clinic Journal of Medicine January 2020, 87 (1) 28-29; DOI: https://doi.org/10.3949/ccjm.87a.19124

    CRISPR-Cas9 makes it possible to edit the patient’s own genes, but questions remain.

Symptoms to Diagnosis

  • Fever in a traveler returning from Ethiopia
    Ken Koon Wong, MD
    Cleveland Clinic Journal of Medicine January 2020, 87 (1) 31-42; DOI: https://doi.org/10.3949/ccjm.87a.19017

    His symptoms began about 10 days after returning and had been going on for 11 days. What was the cause?

Review

  • Sickle cell disease: A primary care update
    Grace Onimoe, MD and Seth Rotz, MD
    Cleveland Clinic Journal of Medicine January 2020, 87 (1) 19-27; DOI: https://doi.org/10.3949/ccjm.87a.18051

    Survival has improved, but patients still face multiorgan damage, chronic anemia, and debilitating pain crises.

  • Cardio-obstetrics: Recognizing and managing cardiovascular complications of pregnancy
    Cardio-obstetrics: Recognizing and managing cardiovascular complications of pregnancy
    Kayle S. Shapero, MD, PhD, Nihar R. Desai, MD, MPH, Robert W. Elder, MD, Heather S. Lipkind, MD, Josephine C. Chou, MD, MS and Erica S. Spatz, MD, MHS
    Cleveland Clinic Journal of Medicine January 2020, 87 (1) 43-52; DOI: https://doi.org/10.3949/ccjm.87a.18137

    Pregnancy can exacerbate known cardiovascular disorders and unmask previously unrecognized problems.

  • Sepsis and septic shock: Guideline-based management
    Siddharth Dugar, MD, Chirag Choudhary, MD, MBA and Abhijit Duggal, MD, MPH, MSc, FACP
    Cleveland Clinic Journal of Medicine January 2020, 87 (1) 53-64; DOI: https://doi.org/10.3949/ccjm.87a.18143

    Sepsis requires prompt recognition, appropriate antibiotics, careful hemodynamic support, and control of the source of infection.

Letters to the Editor

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