Table of Contents
From the Editor
- Modifying genetic diseases: Promises to be realized?
Genetic engineering offers hope to patients and families who previously had little.
The Clinical Picture
- Giant uric acid stone in the bladder
The patient said he had to urinate 30 to 40 times a day, but only in small amounts.
Review
- Sickle cell disease: A primary care update
Survival has improved, but patients still face multiorgan damage, chronic anemia, and debilitating pain crises.
Editorial
- Gene therapy in sickle cell disease: Possible utility and impact
CRISPR-Cas9 makes it possible to edit the patient’s own genes, but questions remain.
Symptoms to Diagnosis
- Fever in a traveler returning from Ethiopia
His symptoms began about 10 days after returning and had been going on for 11 days. What was the cause?
Review
Cardio-obstetrics: Recognizing and managing cardiovascular complications of pregnancyPregnancy can exacerbate known cardiovascular disorders and unmask previously unrecognized problems.
- Sepsis and septic shock: Guideline-based management
Sepsis requires prompt recognition, appropriate antibiotics, careful hemodynamic support, and control of the source of infection.
Commentary
Defibrillators are designed to affect electrical activity in the patient’s heart. Caregivers, be careful!