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The Clinical Picture

Firm lesion on the lateral thigh

Morteza Khodaee, MD, MPH and Eric Kim, MD, PhD
Cleveland Clinic Journal of Medicine July 2020, 87 (7) 394-395; DOI: https://doi.org/10.3949/ccjm.87a.19107
Morteza Khodaee
Associate Professor, Department of Family Medicine, University of Colorado School of Medicine, Denver, CO
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Eric Kim
House Officer, Department of Family Medicine, University of Colorado School of Medicine, Denver, CO
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    Figure 1

    A hyperpigmented nodule on the lateral thigh.

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    Figure 2

    Retraction with lateral compression.

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    TABLE 1

    Differential diagnosis of a firm, hyperpigmented, macular skin lesion

    ConditionCharacteristics
    Lentigo malignaIrregular asymmetric pigmented macules that grow centrifugally
    Dermatofibrosarcoma protuberansSimilar to dermatofibroma, but larger, irregular border, deeper skin invasion
    Seborrheic keratosisShiny (“oily”), well-demarcated macule or papule, “stuck-on” appearance
    Epidermoid inclusion cystFlat or raised flesh-colored cystic lesion; often has dark central punctum; size varies; may spontaneously drain
    DermatofibromaSlow-growing, firm, tan to reddish-brown papules, < 1 cm, that “dimple” to lateral compression
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Cleveland Clinic Journal of Medicine: 87 (7)
Cleveland Clinic Journal of Medicine
Vol. 87, Issue 7
1 Jul 2020
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Firm lesion on the lateral thigh
Morteza Khodaee, Eric Kim
Cleveland Clinic Journal of Medicine Jul 2020, 87 (7) 394-395; DOI: 10.3949/ccjm.87a.19107

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Firm lesion on the lateral thigh
Morteza Khodaee, Eric Kim
Cleveland Clinic Journal of Medicine Jul 2020, 87 (7) 394-395; DOI: 10.3949/ccjm.87a.19107
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    • THE DIFFERENTIAL DIAGNOSIS
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