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Review

Irritable bowel syndrome with diarrhea: Treatment is a work in progress

Michael Kurin, MD and Gregory Cooper, MD
Cleveland Clinic Journal of Medicine August 2020, 87 (8) 501-511; DOI: https://doi.org/10.3949/ccjm.87a.19011
Michael Kurin
Digestive Health Institute, University Hospitals Cleveland Medical Center; Case Western Reserve University School of Medicine, Cleveland, OH
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  • For correspondence: [email protected]
Gregory Cooper
Digestive Health Institute, University Hospitals Cleveland Medical Center; Director of Gastroenterology and Hepatology Fellowship, University Hospitals Cleveland Medical Center; Professor, Department of Medicine, and Professor, Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH
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    Figure 1

    Algorithm for diagnosing irritable bowel syndrome-diarrhea (IBS-D).

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    Figure 2

    Suggested algorithm for treating irritable bowel syndrome-diarrheal type.

Tables

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    TABLE 1

    Diagnoses to consider before irritable bowel syndrome-diarrhea

    Inflammatory bowel disease
    Food intolerance or sensitivity
    Small intestinal bacterial overgrowth
    Bile acid diarrhea
    Pancreatic exocrine deficiency
    Medication side effects
    Functional diarrhea
    Colon cancer
    Chronic parasitic infection
    Microscopic colitis
    Thyroid disease
    Celiac disease
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    TABLE 2

    Alarm signs and symptoms

    Age over 50
    Gastrointestinal bleeding
    Anemia
    Fever
    Night sweats
    Unintentional weight loss
    Family history of organic gastrointestinal disease
    Other symptoms that should alert provider to consider another diagnosis
    Nocturnal symptoms
    Symptoms that persist when fasting
    Low fecal osmotic gap (fecal osmotic gap = 290 mOsm/kg) – 2 × (stool Na + stool K); a low gap (< 50 mOsm/kg) suggests a secretory cause of diarrhea such as microscopic colitis. Patients with IBS would be expected to have a normal gap.
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    TABLE 3

    Proposed diets for irritable bowel syndrome

    Traditional IBS diet
    Eat small, frequent meals
    Reduce gas-producing foods, including:
     Soda
     Juice
     Caffeine
     Beans
     Onions
     Bagels
     Pretzels
     Alcohol
     Wheat
     Certain fruits
    Modified NICE diet
    Eat small, frequent meals
    Limit high-fiber foods
    Avoid:
     Alcohol
     Caffeine
     Soda
     Sorbitol
    Low-FODMAP diet
    Avoid wheat, selected fruits and vegetables, corn syrup, onions
    • FODMAP = fermentable oligosaccharides, disaccharides, mono-saccharides, and polyols; NICE = National Institute for Health and Care Excellence

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Cleveland Clinic Journal of Medicine: 87 (8)
Cleveland Clinic Journal of Medicine
Vol. 87, Issue 8
1 Aug 2020
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Irritable bowel syndrome with diarrhea: Treatment is a work in progress
Michael Kurin, Gregory Cooper
Cleveland Clinic Journal of Medicine Aug 2020, 87 (8) 501-511; DOI: 10.3949/ccjm.87a.19011

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Irritable bowel syndrome with diarrhea: Treatment is a work in progress
Michael Kurin, Gregory Cooper
Cleveland Clinic Journal of Medicine Aug 2020, 87 (8) 501-511; DOI: 10.3949/ccjm.87a.19011
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  • Article
    • ABSTRACT
    • A FUNCTIONAL DISEASE
    • DIAGNOSIS
    • MANAGEMENT
    • THERAPY TARGETING AN UNDERLYING INTESTINAL ABNORMALITY
    • TARGETED THERAPY STILL A WORK IN PROGRESS
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