Vitamin D: A metabolic bone disease perspective

EFFECTS ON BONE

Circulating 25(OH)D is the substrate for physiologically active vitamin D, critical in maintenance of calcium homeostasis and bone integrity. Low vitamin D stimulates an increased parathyroid hormone response, with levels often within the normal range, but it can also cause an elevation above normal.^2,3 An increase in parathyroid hormone will maintain the serum calcium level within the normal range, but at the expense of phosphate excretion and removal of calcium from bone, thus adversely affecting bone strength. Initially this is clinically silent, but a chronically reduced active 25(OH)D substrate level from any cause, whether from poor diet, inadequate sun exposure, or low grade inflammation, will still result in reduced vitamin D compounds and a bone-adverse physiologic effect. A 25(OH)D level of approximately 50 nmol/L (approximately 20 ng/mL) is sufficient to maintain calcium and phosphate homeostasis and prevent osteomalacia and rickets but insufficient to lower fracture risk.^4,5 Higher serum levels of around 75 nmol (30 ng/mL) are needed for bone health^4–6 and are required to reduce risk of nonvertebral and hip fracture.^4,5

It is tempting to add vitamin D supplements if the vitamin D level is below 75 nmol/L (30 ng/mL), but that alone may not reduce fracture risk. In a large, well-designed, double-blind, placebo-controlled study, vitamin D₃ supplementation of 2,000 IU daily without coadministered calcium did not lower risk of fractures, regardless of the baseline 25(OH)D level, even in participants with levels below 12 ng/mL.⁶ The complexity of bone healthcare requires attention to multiple factors and a deeper understanding of the role of vitamin D.

Antonelli and colleagues point out that checking vitamin D levels is recommended in select populations such as patients with osteoporosis, inflammatory bowel disease, kidney and liver disease, and pancreatitis. I would also suggest routinely monitoring patients on medications known to adversely affect vitamin D concentrations and prior to initiating therapy with denosumab, a potent inhibitor of osteoclast activity helpful in treating osteoporosis.

Hypocalcemia is listed as a serious adverse reaction in patients receiving the Prolia brand of denosumab, and the product’s package insert⁷ specifically advises to “adequately supplement all patients with calcium and vitamin D” and “instruct patients to take calcium 1,000 mg daily and at least 400 IU vitamin D daily,”⁷ thus recognizing the important biologic significance of vitamin D in maintaining serum calcium levels.

There are no national published guidelines specifying a minimal vitamin D level, although some National Health Service hospitals in the United Kingdom require that 25(OH)D levels be above 50 nmol/L before administering denosumab.^8,9 Future research may provide evidence-based rationale for maintaining specific quantities of vitamin D in other conditions.

When checking levels, clinicians should keep in mind that vitamin D levels fluctuate by season of the year and time of day, and that different laboratories may use different assays that yield different results. Without supplements or dietary adjustments, a person’s vitamin D serum concentration varies with different amounts of sun exposure. Serum 25(OH)D levels tend to be highest at the end of summer and lowest at the end of winter. There is also a diurnal rhythm, with levels higher during the day and lower at night. Though perhaps not clinically crucial, comparing subsequent vitamin D levels taken at the same season, same time of day, and using the same trusted laboratory will help to assess true changes. For a patient who is acutely ill, as Antonelli et al point out,¹ perhaps it is best to delay testing until the patient recovers.

DISCLOSURES

The author reports no relevant financial relationships which, in the context of his contributions, could be perceived as a potential conflict of interest.