Table of Contents
From the Editor
- The uric acid hypothesis: Out with the old, in with the … old
The death knell for the idea that serum urate mediates cardiovascular disease tolled about 25 years ago. But now the concept is being revived.
Editorial
Review
- Antioxidants and hormones as antiaging therapies: High hopes, disappointing results
We review the evidence of efficacy (or lack thereof) for two types of agents touted as antiaging therapies.
Medical Grand Rounds
- Role of uric acid in hypertension, renal disease, and metabolic syndrome
Clinical gout is just the tip of the iceberg: we believe that elevated uric acid is actually one of the most important risk factors for cardiovascular disease and that it plays a role in renal disease and metabolic syndrome as well.
Review
- Cystic fibrosis in adults: An overview for the internist
Cystic fibrosis is no longer a purely pediatric disease; the median life expectancy is now more than 40 years.
PET and PET/CT imaging: What clinicians need to knowHow positron emission tomography (PET) and PET/computed tomography (PET/CT) work and are showing promise in clinical oncology, cardiology, and neurology.
The Clinical Picture
- A woman with aplastic anemia and a rash
A patient who is receiving multiple drugs, including several antibiotics, develops a rash on her chest, abdomen, and extremities. What is the most likely diagnosis?
Im Board Review
- Hypotension in the intensive care unit
Our patient’s vital signs: temperature 98.4°F, pulse 96 and regular, respirations 23, blood pressure 76/44 mm Hg, central venous pressure 21 mm Hg. What is the likely cause of his hypotension?
Medical Problems in Pregnancy
- Treating depression in pregnancy: Practical suggestions
Treating depression in a pregnant woman is a balance between relieving the mother’s depression and minimizing the baby’s exposure to potentially harmful drugs.
