Table of Contents
From the Editor
- Gene-based, rational drug-dosing: An evolving, complex opportunity
Pharmacogenomics promises the opportunity to match the right drug and dose to the right patient. We are not there yet, but the day is coming.
Medical Grand Rounds
- Ending LGBT invisibility in health care: The first step in ensuring equitable care
Lesbian, gay, bisexual, and transgender individuals experience health care disparities that will be eliminated only if clinicians elicit information in a thoughtful, nonjudgmental way.
The Clinical Picture
- Leukemia cutis
This condition occurs in 10% to 15% of patients with acute myeloid leukemia and is a poor prognostic sign.
Im Board Review
- Nausea, vomiting, and panic attacks in a 50-year-old woman
Six months ago she started to have panic attacks that roused her from sleep. Lately, they have become more frequent and more severe. What is the cause?
Editorial
- Pharmacogenomics for the primary care provider: Why should we care?
Personalized medicine promises to improve the quality and lower the cost of care if physicians integrate into practice useful new findings, such as information gleaned from pharmacogenomic testing.
Review
Pharmacogenomic testing: Relevance in medical practiceKnowing their patients’ genetic status, physicians could predict their response to certain drugs, such as clopidogrel (Plavix), warfarin (Coumadin), tamoxifen (Nolvadex), codeine, and psychotropic medications.
- Managing newly diagnosed atrial fibrillation: Rate, rhythm, and risk
Treatment focuses on controlling the heart rate, preventing thromboembolic events, and, depending on symptoms, restoring and maintaining sinus rhythm.
- Giant cell arteritis: Suspect it, treat it promptly
Giant cell arteritis is the most common form of vasculitis affecting older people. Physicians should be familiar with its variety of clinical presentations.
