Skip to main content

Main menu

  • Home
  • Content
    • Current Issue
    • Ahead of Print
    • Past Issues
    • Supplements
    • Article Type
  • Specialty
    • Articles by Specialty
  • CME/MOC
    • Articles
    • Calendar
  • Info For
    • Manuscript Submission
    • Authors & Reviewers
    • Subscriptions
    • About CCJM
    • Contact Us
    • Media Kit
  • Conversations with Leaders
  • Conference Coverage
    • Kidney Week 2024
    • CHEST 2024
    • ACR Convergence 2023
    • Kidney Week 2023
    • ObesityWeek 2023
    • IDWeek 2023
    • CHEST 2023
    • MDS 2023
    • IAS 2023
    • ACP 2023
    • AAN 2023
    • ACC / WCC 2023
    • AAAAI Meeting 2023
    • ACR Convergence 2022
    • Kidney Week 2022
    • AIDS 2022
  • Other Publications
    • www.clevelandclinic.org

User menu

  • Register
  • Log in

Search

  • Advanced search
Cleveland Clinic Journal of Medicine
  • Other Publications
    • www.clevelandclinic.org
  • Register
  • Log in
Cleveland Clinic Journal of Medicine

Advanced Search

  • Home
  • Content
    • Current Issue
    • Ahead of Print
    • Past Issues
    • Supplements
    • Article Type
  • Specialty
    • Articles by Specialty
  • CME/MOC
    • Articles
    • Calendar
  • Info For
    • Manuscript Submission
    • Authors & Reviewers
    • Subscriptions
    • About CCJM
    • Contact Us
    • Media Kit
  • Conversations with Leaders
  • Conference Coverage
    • Kidney Week 2024
    • CHEST 2024
    • ACR Convergence 2023
    • Kidney Week 2023
    • ObesityWeek 2023
    • IDWeek 2023
    • CHEST 2023
    • MDS 2023
    • IAS 2023
    • ACP 2023
    • AAN 2023
    • ACC / WCC 2023
    • AAAAI Meeting 2023
    • ACR Convergence 2022
    • Kidney Week 2022
    • AIDS 2022
Review

Drugs that may harm bone: Mitigating the risk

Faye N. Hant, DO, MSCR and Marcy B. Bolster, MD
Cleveland Clinic Journal of Medicine April 2016, 83 (4) 281-288; DOI: https://doi.org/10.3949/ccjm.83a.15066
Faye N. Hant
Associate Professor of Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: [email protected]
Marcy B. Bolster
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Article Figures & Data

Tables

    • View popup
    TABLE 1

    Drugs that may harm bone

    Glucocorticoids
    Selective serotonin reuptake inhibitors
    Aromatase inhibitors
    Hypoglycemic agents (thiazolidinediones)
    Proton pump inhibitors
    Antiepileptics
    Anticoagulants (heparin and oral agents)
    Loop diuretics
    Antiretroviral agents
    Calcineurin inhibitors
    Androgen deprivation therapy
    Depot medroxyprogesterone acetate
    • View popup
    TABLE 2

    How to manage drugs that affect bone health

    General recommendations
    Reassess need for medication
    Use lowest dosage and shortest duration needed
    Counsel patients on lifestyle changes: encourage weight-bearing exercise, cessation of tobacco use, and limiting alcohol use
    Supplement calcium and vitamin D
    Consider screening and monitoring bone density with dual-energy absorptiometry (DXA)
    Initiate osteoporosis treatment if indicated
    Oral glucocorticoids
    Therapy anticipated for ≥ 3 months at any dose: get baseline DXA scan
    Follow American College of Rheumatology recommendations for initiating osteoporosis prevention treatment
    Proton pump inhibitors
    Supplement calcium with calcium citrate
    Consider alternative therapy such as a histamine-2 receptor blocker
    Aromatase inhibitors
    Consider bisphosphonate treatment for postmenopausal women with T scores < –2.0 or with other risk factors
PreviousNext
Back to top

In this issue

Cleveland Clinic Journal of Medicine: 83 (4)
Cleveland Clinic Journal of Medicine
Vol. 83, Issue 4
1 Apr 2016
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Cleveland Clinic Journal of Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Drugs that may harm bone: Mitigating the risk
(Your Name) has sent you a message from Cleveland Clinic Journal of Medicine
(Your Name) thought you would like to see the Cleveland Clinic Journal of Medicine web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Drugs that may harm bone: Mitigating the risk
Faye N. Hant, Marcy B. Bolster
Cleveland Clinic Journal of Medicine Apr 2016, 83 (4) 281-288; DOI: 10.3949/ccjm.83a.15066

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Drugs that may harm bone: Mitigating the risk
Faye N. Hant, Marcy B. Bolster
Cleveland Clinic Journal of Medicine Apr 2016, 83 (4) 281-288; DOI: 10.3949/ccjm.83a.15066
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Linkedin Share Button

Jump to section

  • Article
    • ABSTRACT
    • GLUCOCORTICOIDS
    • PROTON PUMP INHIBITORS
    • SELECTIVE SEROTONIN REUPTAKE INHIBITORS
    • ANTIEPILEPTIC DRUGS
    • AROMATASE INHIBITORS
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Alpha-gal syndrome: Recognizing and managing a tick-bite–related meat allergy
  • Managing right ventricular failure in the setting of pulmonary embolism
  • Psychedelics, spirituality, and existential distress in patients at the end of life
Show more Review

Similar Articles

Subjects

  • Drug Therapy
  • Endocrinology
  • Gastroenterology
  • Mental Health
  • Neurology
  • Women's Health

Navigate

  • Current Issue
  • Past Issues
  • Supplements
  • Article Type
  • Specialty
  • CME/MOC Articles
  • CME/MOC Calendar
  • Media Kit

Authors & Reviewers

  • Manuscript Submission
  • Authors & Reviewers
  • Subscriptions
  • About CCJM
  • Contact Us
  • Cleveland Clinic Center for Continuing Education
  • Consult QD

Share your suggestions!

Copyright © 2025 The Cleveland Clinic Foundation. All rights reserved. The information provided is for educational purposes only. Use of this website is subject to the website terms of use and privacy policy. 

Powered by HighWire