Paraneoplastic acral vascular syndrome

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Figure 1
Acrocyanosis of the left hallux with an acral distribution.

TABLE 1

Paraneoplastic dermatoses associated with internal malignancy

Dermatoses	Malignancies
Acquired ichthyosis Diffuse rhomboid scales on trunk and extensor regions	Hodgkin disease, lymphoproliferative disorders
Acrokeratosis paraneoplastica Erythematous desquamating eruption with plaques in acral areas	Squamous cell carcinoma of the upper aerodigestive tract
Leser-Trélat syndrome Sudden appearance of multiple seborrheic keratoses	Gastrointestinal adenocarcinoma; multiple carcinomas and lymphomas
Necrolytic migratory erythema Migratory erythematous papules or macules in a ringlike pattern	Glucagonoma
Acanthosis palmaris^a Velvety palms with exaggerated skin ridges	Lung and gastric carcinoma

↵a Also known as “tripe” palms, as the palms were thought to resemble tripe, a dish made from the rugose foregut of cattle.
Based on information from references 5 and 6.