Skip to main content

Main menu

  • Home
  • Content
    • Current Issue
    • Ahead of Print
    • Past Issues
    • Supplements
    • Article Type
  • Specialty
    • Articles by Specialty
  • CME/MOC
    • Articles
    • Calendar
  • Info For
    • Manuscript Submission
    • Authors & Reviewers
    • Subscriptions
    • About CCJM
    • Contact Us
    • Media Kit
  • Conversations with Leaders
  • Conference Coverage
    • Kidney Week 2024
    • CHEST 2024
    • ACR Convergence 2023
    • Kidney Week 2023
    • ObesityWeek 2023
    • IDWeek 2023
    • CHEST 2023
    • MDS 2023
    • IAS 2023
    • ACP 2023
    • AAN 2023
    • ACC / WCC 2023
    • AAAAI Meeting 2023
    • ACR Convergence 2022
    • Kidney Week 2022
    • AIDS 2022
  • Other Publications
    • www.clevelandclinic.org

User menu

  • Register
  • Log in

Search

  • Advanced search
Cleveland Clinic Journal of Medicine
  • Other Publications
    • www.clevelandclinic.org
  • Register
  • Log in
Cleveland Clinic Journal of Medicine

Advanced Search

  • Home
  • Content
    • Current Issue
    • Ahead of Print
    • Past Issues
    • Supplements
    • Article Type
  • Specialty
    • Articles by Specialty
  • CME/MOC
    • Articles
    • Calendar
  • Info For
    • Manuscript Submission
    • Authors & Reviewers
    • Subscriptions
    • About CCJM
    • Contact Us
    • Media Kit
  • Conversations with Leaders
  • Conference Coverage
    • Kidney Week 2024
    • CHEST 2024
    • ACR Convergence 2023
    • Kidney Week 2023
    • ObesityWeek 2023
    • IDWeek 2023
    • CHEST 2023
    • MDS 2023
    • IAS 2023
    • ACP 2023
    • AAN 2023
    • ACC / WCC 2023
    • AAAAI Meeting 2023
    • ACR Convergence 2022
    • Kidney Week 2022
    • AIDS 2022
Review

The effect of disease-modifying antirheumatic drugs on vaccine immunogenicity in adults

Alvin Lee Day, MD, Kevin L. Winthrop, MD, MPH and Jeffrey R. Curtis, MD, MS, MPH
Cleveland Clinic Journal of Medicine November 2020, 87 (11) 695-703; DOI: https://doi.org/10.3949/ccjm.87a.20056
Alvin Lee Day
Clinical Assistant Professor, Division of Rheumatology, Palmetto Health/University of South Carolina School of Medicine, Columbia, SC
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kevin L. Winthrop
Professor, Division of Infectious Diseases, Oregon Health and Science University, Portland, OR
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jeffrey R. Curtis
Professor, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: [email protected]
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

ABSTRACT

Patients with immunocompromising conditions are at higher risk of vaccine-preventable infections. Further, those receiving immunosuppressive disease-modifying antirheumatic drugs (DMARDs) can have variable responses to vaccines depending on which vaccine and which DMARD they are receiving.

Footnotes

  • Dr. Winthrop has disclosed consulting for Abbvie Pharmaceuticals, Bristol-Myers Squibb, Eli Lilly, Galapagos, Genentech/Roche, Gilead Sciences, GlaxoSmithKline, Pfizer, Regeneron, Sanofi, and UCB.

    Dr. Curtis has disclosed consulting, speaking, or honoraria for Abbvie, Amgen, BMS, Corona, Gilead, Janssen, Lilly, Myriad, Novartis, Pfizer, Sanofi, and Scipher.

    Dr. Day reports no relevant financial relationships which, in the context of his contribution, could be perceived as a potential conflict of interest.

  • Copyright © 2020 The Cleveland Clinic Foundation. All Rights Reserved.
View Full Text
  1. Alvin Lee Day, MD
  1. Clinical Assistant Professor, Division of Rheumatology, Palmetto Health/University of South Carolina School of Medicine, Columbia, SC
  1. Kevin L. Winthrop, MD, MPH
  1. Professor, Division of Infectious Diseases, Oregon Health and Science University, Portland, OR
  1. Jeffrey R. Curtis, MD, MS, MPH⇑
  1. Professor, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL
  1. Address:
    Jeffrey R. Curtis, MD, MS, MPH, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, 1720 2nd Avenue South, FOT 839, Birmingham, AL 35294; jrcurtis{at}uabmc.edu

ABSTRACT

Patients with immunocompromising conditions are at higher risk of vaccine-preventable infections. Further, those receiving immunosuppressive disease-modifying antirheumatic drugs (DMARDs) can have variable responses to vaccines depending on which vaccine and which DMARD they are receiving.

Footnotes

  • Dr. Winthrop has disclosed consulting for Abbvie Pharmaceuticals, Bristol-Myers Squibb, Eli Lilly, Galapagos, Genentech/Roche, Gilead Sciences, GlaxoSmithKline, Pfizer, Regeneron, Sanofi, and UCB.

    Dr. Curtis has disclosed consulting, speaking, or honoraria for Abbvie, Amgen, BMS, Corona, Gilead, Janssen, Lilly, Myriad, Novartis, Pfizer, Sanofi, and Scipher.

    Dr. Day reports no relevant financial relationships which, in the context of his contribution, could be perceived as a potential conflict of interest.

  • Copyright © 2020 The Cleveland Clinic Foundation. All Rights Reserved.
View Full Text
PreviousNext
Back to top

In this issue

Cleveland Clinic Journal of Medicine: 87 (11)
Cleveland Clinic Journal of Medicine
Vol. 87, Issue 11
1 Nov 2020
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Complete Issue (PDF)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Cleveland Clinic Journal of Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
The effect of disease-modifying antirheumatic drugs on vaccine immunogenicity in adults
(Your Name) has sent you a message from Cleveland Clinic Journal of Medicine
(Your Name) thought you would like to see the Cleveland Clinic Journal of Medicine web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
The effect of disease-modifying antirheumatic drugs on vaccine immunogenicity in adults
Alvin Lee Day, Kevin L. Winthrop, Jeffrey R. Curtis
Cleveland Clinic Journal of Medicine Nov 2020, 87 (11) 695-703; DOI: 10.3949/ccjm.87a.20056

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
The effect of disease-modifying antirheumatic drugs on vaccine immunogenicity in adults
Alvin Lee Day, Kevin L. Winthrop, Jeffrey R. Curtis
Cleveland Clinic Journal of Medicine Nov 2020, 87 (11) 695-703; DOI: 10.3949/ccjm.87a.20056
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Linkedin Share Button

Jump to section

  • Article
    • ABSTRACT
    • IMMUNE-MEDIATED INFLAMMATORY DISEASES AND INFECTION
    • INFLUENZA VACCINATION
    • PNEUMOCOCCAL VACCINATION
    • HERPES ZOSTER VACCINATION
    • HEPATITIS B VACCINATION
    • HUMAN PAPILLOMAVIRUS VACCINATION
    • TAKE-HOME POINTS
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • Persistently reduced humoral and cellular immune response following third SARS-CoV-2 mRNA vaccination in anti-CD20-treated multiple sclerosis patients
  • Immunogenicity and safety of anti-SARS-CoV-2 mRNA vaccines in patients with chronic inflammatory conditions and immunosuppressive therapy in a monocentric cohort
  • Rheumatology and COVID-19 at 1 year: facing the unknowns
  • Glucocorticoids and B Cell Depleting Agents Substantially Impair Immunogenicity of mRNA Vaccines to SARS-CoV-2
  • Google Scholar

More in this TOC Section

  • Alpha-gal syndrome: Recognizing and managing a tick-bite–related meat allergy
  • Managing right ventricular failure in the setting of pulmonary embolism
  • Nociplastic pain: A practical guide to chronic pain management in the primary care setting
Show more Review

Similar Articles

Subjects

  • Allergy/Immunology
  • Drug Therapy
  • Preventive Care
  • Rheumatology

Navigate

  • Current Issue
  • Past Issues
  • Supplements
  • Article Type
  • Specialty
  • CME/MOC Articles
  • CME/MOC Calendar
  • Media Kit

Authors & Reviewers

  • Manuscript Submission
  • Authors & Reviewers
  • Subscriptions
  • About CCJM
  • Contact Us
  • Cleveland Clinic Center for Continuing Education
  • Consult QD

Share your suggestions!

Copyright © 2025 The Cleveland Clinic Foundation. All rights reserved. The information provided is for educational purposes only. Use of this website is subject to the website terms of use and privacy policy. 

Powered by HighWire