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Review

Chronic venous outflow obstruction: An important cause of chronic venous disease

Matthew Harris, MBBS, MRCS and Chung Sim Lim, MBBS, PhD, FRCS, FEBVS
Cleveland Clinic Journal of Medicine December 2021, 88 (12) 680-688; DOI: https://doi.org/10.3949/ccjm.88a.21068
Matthew Harris
Specialty Registrar in Vascular Surgery, The Royal Free London NHS Foundation Trust, London, United Kingdom
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Chung Sim Lim
Consultant Vascular and Endovascular Surgeon, Cleveland Clinic London and The Royal Free London NHS Foundation Trust, London, United Kingdom
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    Figure 1

    Venous eczema associated with chronic venous insufficiency of the lower limbs. The condition is worse on the right leg.

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    Figure 2

    Severe venous ulceration associated with chronic venous insufficiency. Venous ulceration typically occurs in the ankle (gaiter) with surrounding skin changes such as venous eczema (purplish discoloration around the ulcer) and lipodermatosclerosis as well as edema. No clinical feature of the ulcer indicates that chronic venous outflow obstruction (CVOO) is the cause, but the severity of the disease is often worse with CVOO than with superficial venous incompetence, although not exclusive.

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    Figure 3

    Contrast venography and intravascular ultrasonography of a 44-year-old man with obstructed left iliofemoral vein secondary to postthrombotic syndrome just before and after stenting. (A) Prestenting contrast venography shows complete obstruction of the left iliofemoral vein. The venous return of the left leg is through collateral veins (black arrow). (B) Poststenting contrast venography shows patent left iliofemoral vein following balloon angioplasty and stent placement with disappearance of the collateral veins. (C) Prestenting intravascular ultrasonography of the left common iliac vein shows that the vein (white arrow) is obstructed and compressed by the right common iliac artery (RCIA). (D) Poststenting intravascular ultrasonography of the left common iliac vein (LCIV) at the same level as in C shows the lumen of the vein is patent and maintained by the stent (white arrow). (IVC = inferior vena cava; LCFV = left common femoral vein; LEIV = left external iliac vein)

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    TABLE 1

    Evaluating the severity of postthrombotic syndrome (PTS): The Villalta-Prandoni scale

    No PTSMildModerateSevere
    Symptoms
    Pain0123
    Cramps0123
    Heaviness0123
    Paresthesia0123
    Pruritus0123
    Clinical signs
    Pretibial edema0123
    Skin induration0123
    Hyperpigmentation0123
    Redness0123
    Venous ectasia0123
    Pain on calf compression0123
    Venous ulcerAbsentPresent
    Severity score
    None < 5
    Mild 5-9
    Moderate 10-14
    Severe > 14, with or without venous ulcer
    • Based on information in reference 8.

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    TABLE 2

    Clinical features of chronic venous outflow obstruction

    Swelling affecting the whole leg, including the pelvis, groin, and hip
    Venous claudication, often described as pain and heaviness of the whole leg that may be associated with shortness of breath and tiredness on walking due to reduced venous return
    Persistent features of chronic venous insufficiency such as nonhealing venous ulcers despite adequate treatment, or absence of superficial and deep venous incompetence
    History of venous thromboembolism, central venous catheterization, abdominal or pelvic surgery, and recreational intravenous drug use
    The presence of dilated collateral veins in the groin, genitalia, abdomen, and pelvis
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Cleveland Clinic Journal of Medicine: 88 (12)
Cleveland Clinic Journal of Medicine
Vol. 88, Issue 12
1 Dec 2021
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Chronic venous outflow obstruction: An important cause of chronic venous disease
Matthew Harris, Chung Sim Lim
Cleveland Clinic Journal of Medicine Dec 2021, 88 (12) 680-688; DOI: 10.3949/ccjm.88a.21068

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Chronic venous outflow obstruction: An important cause of chronic venous disease
Matthew Harris, Chung Sim Lim
Cleveland Clinic Journal of Medicine Dec 2021, 88 (12) 680-688; DOI: 10.3949/ccjm.88a.21068
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  • Article
    • ABSTRACT
    • CHALLENGES: QUALITY OF LIFE, TREATMENT OPTIONS
    • WHAT CAUSES CVOO?
    • THE INITIAL ASSESSMENT
    • IMAGING: STRENGTHS AND LIMITATIONS
    • MANAGEMENT STRATEGIES
    • REFERRAL AND INTERVENTION
    • TAKE-HOME MESSAGES
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