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Symptoms to Diagnosis

A 60-year-old man with prostate cancer and embolic strokes

Neha K. Reddy, MD, MA, Christian Scherer, DO, Samuel Kessel, MD, MBA and Alejandro Moreno, MBBS, MPH, JD, MACP
Cleveland Clinic Journal of Medicine December 2022, 89 (12) 705-711; DOI: https://doi.org/10.3949/ccjm.89a.21079
Neha K. Reddy
Department of Internal Medicine, The University of Texas at Austin, Dell Medical School, Austin, TX
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Christian Scherer
Department of Internal Medicine, The University of Texas at Austin, Dell Medical School, Austin, TX
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Samuel Kessel
Department of Internal Medicine, The University of Texas at Austin, Dell Medical School, Austin, TX
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Alejandro Moreno
Professor and Assistant Dean of Clinical Skills Integration, Department of Internal Medicine and Department of Medical Education, The University of Texas at Austin, Dell Medical School, Austin, TX
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    Figure 1

    (A) Initial noncontrast computed tomography (CT) shows no gross abnormalities. (B) The mismatch perfusion CT image shows abnormal perfusion in the left middle cerebral artery, inferior division distribution (CBF = cerebral blood flow; Tmax = time to maximum).

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    Figure 2

    Transthoracic echocardiography showed a new mitral valve vegetation (arrow) on the apical four-chamber view.

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    TABLE 1

    The patient’s laboratory findings

    TestHospital day 1Hospital day 2Hospital day 3Reference range
    Hemoglobin (g/dL)9.47.97.513.5–17.5
    Hematocrit (%)29.0%23.7%21%38.8%–50%
    Platelet count (× 109/L)13711077150–450
    Prothrombin time (seconds)13.617.524.19.5–11.6
    International normalized ratio1.191.532.140.9–1.2
    Activated partial thromboplastin time (seconds)33.738.13823–29
    Fibrinogen (g/L)1.491.190.772.33–4.96
    D-dimer (ng/mL)36,88138,13633,603220–740
    Alkaline phosphatase (IU/L)253——40–150
    Troponin I (ng/mL)1.75——0–0.4
    C-reactive protein (mg/dL)—2.7—< 0.5
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    TABLE 2

    International Society of Thrombosis and Hemostasis scoring system for disseminated intravascular coagulopathy

    Points
    Platelet count
    > 100 × 109/L0
    50–100 × 109/L1
    < 50 × 109/L2
    D-dimer level
    No change0
    Moderate increase1
    Strong increase2
    Prothrombin time
    ≤ 3 seconds0
    > 3 to 6 seconds1
    > 6 seconds2
    Fibrinogen level
    > 1 g/L0
    ≤ 1 g/L1
    Sum of points
    < 5: not suggestive of overt DIC (repeat in 1 to 2 days)
    ≥ 5: suggestive of overt DIC (repeat daily)
    • DIC = disseminated intravascular coagulopathy

    • Based on information in reference 15.

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Cleveland Clinic Journal of Medicine: 89 (12)
Cleveland Clinic Journal of Medicine
Vol. 89, Issue 12
1 Dec 2022
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A 60-year-old man with prostate cancer and embolic strokes
Neha K. Reddy, Christian Scherer, Samuel Kessel, Alejandro Moreno
Cleveland Clinic Journal of Medicine Dec 2022, 89 (12) 705-711; DOI: 10.3949/ccjm.89a.21079

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A 60-year-old man with prostate cancer and embolic strokes
Neha K. Reddy, Christian Scherer, Samuel Kessel, Alejandro Moreno
Cleveland Clinic Journal of Medicine Dec 2022, 89 (12) 705-711; DOI: 10.3949/ccjm.89a.21079
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  • Article
    • INITIAL EXAMINATION AND STUDIES
    • DAY 2: ANOTHER STROKE, ON THE OTHER SIDE
    • CAUSES OF EMBOLIC STROKE
    • DAY 3: BLEEDING
    • DISSEMINATED INTRAVASCULAR COAGULOPATHY
    • A NEW MITRAL VEGETATION, MULTIPLE INFARCTS
    • NONBACTERIAL THROMBOTIC ENDOCARDITIS
    • DISCLOSURES
    • REFERENCES
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