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Symptoms to Diagnosis

Microangiopathic hemolytic anemia in a female patient with systemic lupus erythematosus

Mohammad A. Sohail, MD, Peter Luong, John Sedor, MD and Roop Kaw, MD
Cleveland Clinic Journal of Medicine March 2022, 89 (3) 130-138; DOI: https://doi.org/10.3949/ccjm.89a.21066
Mohammad A. Sohail
Internal Medicine Residency Program, Cleveland Clinic, Cleveland, OH
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  • For correspondence: [email protected]
Peter Luong
Case Western Reserve University, Cleveland, OH
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John Sedor
Department of Kidney Medicine, Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, OH; Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
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Roop Kaw
Department of Hospital Medicine, Department of Outcomes Research, Cleveland Clinic, Cleveland, OH; Professor of Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
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    Figure 1

    Peripheral smear. The yellow arrow indicates a schistocyte (hematoxylin and eosin stain, magnification × 400).

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    TABLE 1

    Irregular patient laboratory results

    TestPatient valueReference range
    Hemoglobin, g/dL11.812.3–15.3
    Hematocrit, %36.036.0–46.0
    White blood cell count, × 109/L2.623.70–11.0
    Absolute lymphocyte count, × 109/L0.551.00–4.00
    Platelet count, × 109/L30150–400
    Serum creatinine, mg/dL1.820.58–0.96
    Alanine aminotransferase, U/L657–38
    Aspartate aminotransferase, U/L14813–35
    C-reactive protein, mg/dL7.3< 0.9
    Lactate dehydrogenase, U/L1317135–214
    Reticulocyte count, %8.70.4–2.0
    Absolute reticulocyte count, × 109/L34818–100
    Haptoglobin, mg/dL< 1031–238
    Fibrinogen, mg/dL411200–400
    D-dimer, ng/mL2900< 500
    Protein-to-creatinine ratio1.7< 0.2
    Urine
     ClarityCloudyClear
     Hemoglobin, mg/dL3+Negative
     Protein, mg/dL≥ 300Negative
     White blood cell count, cells/high-power field6–100–5
     Red blood cell count, cells/high-power field> 250–3
     Protein-to-creatinine ratio1.7< .2
    C3, g/dL2986–166
    C4, g/dL1013–64
    dsDNA, IU/mL> 1000< 30
    ADAMTS13, %54> 60
    • ADAMTS13 = a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13

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Cleveland Clinic Journal of Medicine: 89 (3)
Cleveland Clinic Journal of Medicine
Vol. 89, Issue 3
1 Mar 2022
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Microangiopathic hemolytic anemia in a female patient with systemic lupus erythematosus
Mohammad A. Sohail, Peter Luong, John Sedor, Roop Kaw
Cleveland Clinic Journal of Medicine Mar 2022, 89 (3) 130-138; DOI: 10.3949/ccjm.89a.21066

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Microangiopathic hemolytic anemia in a female patient with systemic lupus erythematosus
Mohammad A. Sohail, Peter Luong, John Sedor, Roop Kaw
Cleveland Clinic Journal of Medicine Mar 2022, 89 (3) 130-138; DOI: 10.3949/ccjm.89a.21066
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  • Article
    • EMERGENCY DEPARTMENT EVALUATION
    • IMPLICATIONS OF HEMOLYTIC ANEMIA WITH THROMBOCYTOPENIA
    • What was the cause of this patient’s TMA?
    • CASE CONTINUED: CONDITION WORSENED
    • WOULD KIDNEY BIOPSY HAVE HELPED?
    • SUBSEQUENT CLINICAL COURSE
    • WHICH MANAGEMENT STRATEGY?
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