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Review

Most elderly patients with subclinical hypothyroidism do not need to be treated

Risheng Xu, DO, Nicola Abate, MD, Nalini Ram, MD and Kristina Little, MD
Cleveland Clinic Journal of Medicine April 2025, 92 (4) 221-231; DOI: https://doi.org/10.3949/ccjm.92a.24098
Risheng Xu
CHI St. Luke’s Health-The Vintage Hospital, Houston, TX; Assistant Professor, Department of Medicine, Baylor College of Medicine, Houston, TX
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  • For correspondence: [email protected]
Nicola Abate
Bay Area Metabolic Health, Houston, TX
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Nalini Ram
Professor, Department of Medicine, Division of Endocrinology, Baylor College of Medicine, Houston, TX
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Kristina Little
Assistant Professor, Department of Medicine, Division of Geriatrics, Baylor College of Medicine, Houston, TX
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Article Information

vol. 92 no. 4 221-231
DOI 
https://doi.org/10.3949/ccjm.92a.24098
PubMed 
40169223

Published By 
Cleveland Clinic Journal of Medicine
Print ISSN 
0891-1150
Online ISSN 
1939-2869
History 
  • Published online April 1, 2025.

Copyright & Usage 
Copyright © 2025 The Cleveland Clinic Foundation. All Rights Reserved.

Author Information

  1. Risheng Xu, DO⇑
  1. CHI St. Luke’s Health-The Vintage Hospital, Houston, TX; Assistant Professor, Department of Medicine, Baylor College of Medicine, Houston, TX
  1. Address:
    Risheng Xu, DO, Department of Medicine, Baylor College of Medicine, 20171 Chasewood Park Drive, Houston, TX 77070; risheng.xu{at}bcm.edu
  1. Nicola Abate, MD
  1. Bay Area Metabolic Health, Houston, TX
  1. Nalini Ram, MD
  1. Professor, Department of Medicine, Division of Endocrinology, Baylor College of Medicine, Houston, TX
  1. Kristina Little, MD
  1. Assistant Professor, Department of Medicine, Division of Geriatrics, Baylor College of Medicine, Houston, TX

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Cleveland Clinic Journal of Medicine: 92 (4)
Cleveland Clinic Journal of Medicine
Vol. 92, Issue 4
1 Apr 2025
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Most elderly patients with subclinical hypothyroidism do not need to be treated
Risheng Xu, Nicola Abate, Nalini Ram, Kristina Little
Cleveland Clinic Journal of Medicine Apr 2025, 92 (4) 221-231; DOI: 10.3949/ccjm.92a.24098

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Most elderly patients with subclinical hypothyroidism do not need to be treated
Risheng Xu, Nicola Abate, Nalini Ram, Kristina Little
Cleveland Clinic Journal of Medicine Apr 2025, 92 (4) 221-231; DOI: 10.3949/ccjm.92a.24098
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Jump to section

  • Article
    • ABSTRACT
    • PRIMARILY A LABORATORY DIAGNOSIS
    • COMMON IN THE ELDERLY
    • MANY FACTORS AFFECT TSH LEVELS
    • IS THE UPPER LIMIT OF NORMAL FOR TSH TOO HIGH?
    • WHY DOES TSH RISE WITH AGE?
    • IS SUBCLINICAL HYPOTHYROIDISM HARMFUL? IS TREATMENT BENEFICIAL?
    • HARMS OF OVERTREATMENT
    • GUIDELINES AND RECOMMENDATIONS
    • MANAGEMENT CHALLENGES
    • PHYSICIAN DECISION-MAKING AND ALTERNATIVES
    • A PERSONALIZED APPROACH
    • DISCLOSURES
    • Acknowledgments
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

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