Table of Contents
From the Editor
- Low bone density is not always bisphosphonate deficiency
Low bone density is not a one-size-fits-all disorder. We need to carefully consider the diagnostic and therapeutic options before assuming that low bone density is osteoporosis.
Editorial
- Treating the renal patient who has a fracture: Opinion vs evidence
The patient with chronic renal disease who has a fracture remains a unique management challenge. Opinions on treatment abound, but without adequate evidence to back them up.
1-Minute Consult
- Is an ACE inhibitor plus an ARB more effective than either drug alone?
No. Dual renin-angiotensin system blockade has never been shown to reduce the rates of morbidity or death from any cause.
Review
Acute pancreatitis: Problems in adherence to guidelinesEvidence-based guidelines on managing acute pancreatitis are available, but many physicians are not following them.
Current Drug Therapy
- Prasugrel for acute coronary syndromes: Faster, more potent, but higher bleeding risk
Prasugrel (Effient) is faster and more consistent in its effects, but patients at high bleeding risk should still receive clopidogrel (Plavix).
Review
- Fragility fractures in chronic kidney disease: An opinion-based approach
When a patient with chronic kidney disease suffers a fragility fracture, a key question is whether the patient has osteoporosis or, instead, renal osteodystrophy. Bone densitometry does not help in this distinction.
- An algorithm for managing warfarin resistance
Some patients need higher-than-expected doses of warfarin to reach their target INR. The cause can be acquired (poor compliance, drug interactions) or hereditary.
