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Review

Functional heartburn: An underrecognized cause of PPI-refractory symptoms

Scott Gabbard, MD and Sonya Vijayvargiya,
Cleveland Clinic Journal of Medicine December 2019, 86 (12) 799-806; DOI: https://doi.org/10.3949/ccjm.86a.19006
Scott Gabbard
Department of Gastroenterology, Hepatology & Nutrition, Cleveland Clinic; Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
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  • For correspondence: gabbars@ccf.org
Sonya Vijayvargiya
Emory University, Atlanta, GA
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ABSTRACT

Functional heartburn—persistent symptoms of esophageal reflux with no objective evidence of gastroesophageal reflux disease (GERD)—is the most common cause of failure of proton pump inhibitor (PPI) therapy, but it is often overlooked by internists and gastroenterologists.

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Cleveland Clinic Journal of Medicine: 86 (12)
Cleveland Clinic Journal of Medicine
Vol. 86, Issue 12
1 Dec 2019
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Functional heartburn: An underrecognized cause of PPI-refractory symptoms
Scott Gabbard, Sonya Vijayvargiya
Cleveland Clinic Journal of Medicine Dec 2019, 86 (12) 799-806; DOI: 10.3949/ccjm.86a.19006

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Functional heartburn: An underrecognized cause of PPI-refractory symptoms
Scott Gabbard, Sonya Vijayvargiya
Cleveland Clinic Journal of Medicine Dec 2019, 86 (12) 799-806; DOI: 10.3949/ccjm.86a.19006
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  • Article
    • ABSTRACT
    • HEARTBURN IS A SYMPTOM; GERD IS A CONDITION
    • PATHOPHYSIOLOGY IS POORLY UNDERSTOOD
    • DIAGNOSTIC EVALUATION
    • CASE CONTINUED:NORMAL RESULTS ON TESTING
    • TREATMENT
    • CASE FOLLOW-UP: IMPROVEMENT WITH TREATMENT
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