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Review

Discontinuing antidepressants: Pearls and pitfalls

Samantha J. Zwiebel, MD and Adele C. Viguera, MD
Cleveland Clinic Journal of Medicine January 2022, 89 (1) 18-26; DOI: https://doi.org/10.3949/ccjm.89a.21020
Samantha J. Zwiebel
Assistant Professor of Clinical Psychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA
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  • For correspondence: [email protected]
Adele C. Viguera
Staff Psychiatrist, Department of Psychiatry, Neurological Institute, Cleveland Clinic, Cleveland, OH; Clinical Assistant Professor of Psychiatry, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
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Article Information

vol. 89 no. 1 18-26
DOI 
https://doi.org/10.3949/ccjm.89a.21020
PubMed 
34983798

Published By 
Cleveland Clinic Journal of Medicine
Print ISSN 
0891-1150
Online ISSN 
1939-2869
History 
  • Published online January 4, 2022.

Copyright & Usage 
Copyright © 2022 The Cleveland Clinic Foundation. All Rights Reserved.

Author Information

  1. Samantha J. Zwiebel, MD⇑
  1. Assistant Professor of Clinical Psychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA
  1. Address:
    Samantha J. Zwiebel, MD, Assistant Professor of Clinical Psychiatry, Department of Psychiatry, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104; zwiebels{at}pennmedicine.upenn.edu
  1. Adele C. Viguera, MD
  1. Staff Psychiatrist, Department of Psychiatry, Neurological Institute, Cleveland Clinic, Cleveland, OH; Clinical Assistant Professor of Psychiatry, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
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Cleveland Clinic Journal of Medicine: 89 (1)
Cleveland Clinic Journal of Medicine
Vol. 89, Issue 1
1 Jan 2022
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Discontinuing antidepressants: Pearls and pitfalls
Samantha J. Zwiebel, Adele C. Viguera
Cleveland Clinic Journal of Medicine Jan 2022, 89 (1) 18-26; DOI: 10.3949/ccjm.89a.21020

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Discontinuing antidepressants: Pearls and pitfalls
Samantha J. Zwiebel, Adele C. Viguera
Cleveland Clinic Journal of Medicine Jan 2022, 89 (1) 18-26; DOI: 10.3949/ccjm.89a.21020
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  • Article
    • ABSTRACT
    • SYMPTOMS AND RISK OF ANTIDEPRESSANT DISCONTINUATION
    • DISCONTINUATION SYNDROME VS WITHDRAWAL
    • THE PHARMACOKINETICS BEHIND DISCONTINUATION SYNDROME
    • WHO IS MOST AT RISK OF DISCONTINUATION SYMPTOMS?
    • PREVENTING AND MANAGING DISCONTINUATION SYMPTOMS
    • TAPERING TO CHANGE ANTIDEPRESSANT MEDICATIONS
    • FUTURE DIRECTIONS
    • TAKE-HOME POINTS
    • DISCLOSURES
    • REFERENCES
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  • PDF

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