Review

Esophageal adenocarcinoma: A dire need for early detection and treatment

Abel Joseph, MD, Siva Raja, MD, PhD, Suneel Kamath, MD, Sunguk Jang, MD, Daniela Allende, MD, Mike McNamara, MD, Gregory Videtic, MD, Sudish Murthy, MD and Amit Bhatt, MD
Cleveland Clinic Journal of Medicine May 2022, 89 (5) 269-279; DOI: https://doi.org/10.3949/ccjm.89a.21053

ABSTRACT

Esophageal cancer is the sixth most common cause of cancer-related death worldwide. Esophageal adenocarcinoma is the most common subtype of esophageal cancer in the United States, and its incidence has risen dramatically in the last few decades. Modern endoscopic and surgical techniques have significantly improved morbidity and mortality rates of patients undergoing treatment for esophageal cancer. However, most cases are diagnosed at a late stage when the prognosis is poor, emphasizing the need for an effective screening strategy. This clinical overview focuses on screening, multidisciplinary evaluation, and treatment of early esophageal adenocarcinoma.

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  1. Abel Joseph, MD⇑
  1. Department of Internal Medicine, Cleveland Clinic, Cleveland, OH
  1. Address:
    Abel Joseph, MD, Department of Internal Medicine, NA1, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195; abeljosephmd{at}gmail.com
  1. 17512-siva-rajaSiva Raja, MD, PhD
  1. Department of Thoracic and Cardiovascular Surgery, Heart, Vascular, and Thoracic Institute, Cleveland Clinic; Associate Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
  1. 25034-suneel-kamathSuneel Kamath, MD
  1. Department of Hematology and Medical Oncology, Cleveland Clinic; Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
  1. 7662-sunguk-jangSunguk Jang, MD
  1. Department of Gastroenterology and Hepatology, Cleveland Clinic; Associate Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
  1. 13794-daniela-allendeDaniela Allende, MD
  1. Department of Pathology, Cleveland Clinic; Associate Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
  1. 9072-michael-mcnamaraMike McNamara, MD
  1. Department of Hematology and Medical Oncology, Cleveland Clinic; Clinical Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
  1. 4918-gregory-videticGregory Videtic, MD
  1. Department of Radiation Oncology, Cleveland Clinic; Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
  1. 3226-sudish-murthySudish Murthy, MD
  1. Department of Thoracic and Cardiovascular Surgery, Heart, Vascular, and Thoracic Institute, Cleveland Clinic; Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
  1. 9192-amit-bhattAmit Bhatt, MD
  1. Department of Gastroenterology and Hepatology, Cleveland Clinic; Clinical Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH

ABSTRACT

Esophageal cancer is the sixth most common cause of cancer-related death worldwide. Esophageal adenocarcinoma is the most common subtype of esophageal cancer in the United States, and its incidence has risen dramatically in the last few decades. Modern endoscopic and surgical techniques have significantly improved morbidity and mortality rates of patients undergoing treatment for esophageal cancer. However, most cases are diagnosed at a late stage when the prognosis is poor, emphasizing the need for an effective screening strategy. This clinical overview focuses on screening, multidisciplinary evaluation, and treatment of early esophageal adenocarcinoma.

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